摘要
目的研究鲍曼不动杆菌血流感染患者的临床特征、感染危险因素及细菌耐药性。方法回顾性分析我院2001年1月至2006年12月间由鲍曼不动杆菌所致血流感染患者的临床及微生物学资料。结果21例患者入选，病死率33．3％。所有患者均有发热，发生血流感染时血白细胞计数平均14．5×10^9／L（4．77×10^9～36．01×10^9／L）。患者有手术史10例，中心静脉导管14例，气管插管或气管切开13例，原发感染灶不明10例（47．6％），继发于下呼吸道感染9例（42．9％），中心静脉插管来源的3例，其他感染灶包括外科伤口等2例。死亡组与存活组相比APACHEⅡ评分高，死亡组菌株耐药性高于存活组。结论鲍曼不动杆菌血流感染病死率高，且多为耐药菌株感染，应引起重视。
Objective To study the clinical characteristic, risk factors and antimicrobial resistance of bloodstream infections caused by A. baumannii. Methods Patients with bloodstream infection caused by A. baumannii in our hospital from January 2001 to December 2006 were retrospectively reviewed. Results A total of 21 patients were found with bloodstream infection caused by A. baumannii during the 5-year period. The mortality rate was 33.3%. All the patients had fever and white cell count was 14. 5 × 10^9/L （4.77 × 10^9 - 36. 01×10^9/L）. Ten patients had received surgical operation within the last 7 days. Fourteen patients had intravascular catheter. Thirteen patients had received mechanical ventilation. The bloodstream infection was due to unknown cause in 10 patients （47.6%）, secondary to lower respiratory tract infection in 9 patients and following intravascular catheter related infection in 3 patients. Compared with the survived patients, the APACHE Ⅱ score was higher and the isolates were more resistant in the patients finally died. Conclusions Most A. baumannii isolates from bloodstream infection are multi-drug resistant and are associated with high mortality rate.
出处
《中国感染与化疗杂志》
CAS
2008年第2期126-129,共4页
Chinese Journal of Infection and Chemotherapy
关键词
鲍曼不动杆菌
血流感染
耐药性
Acinetobacter baumannii
Bloodstream infection
Antimicrobial resistance
