摘要
目的探讨低自由基香烟(实验烟)烟气对大鼠血液生化指标、骨髓嗜多染红细胞微核、气管及肺的影响。方法将36只SD大鼠随机分为3组(空白对照组、对照烟组和实验烟组),雌雄各半,每组12只。对照烟组和实验烟组大鼠均被动吸烟30d,每天12支,然后分别检测3组大鼠的血液生化指标,用Giemsa法和HE法染色后对大鼠骨髓嗜多染红细胞微核发生情况、气管及肺的病理组织进行观察。结果实验烟组和对照烟组大鼠血液生化指标比较,差异无统计学意义(P>0.05);骨髓嗜多染性红细胞微核率比较,差异无统计学意义(P>0.05),表明未增加新的致突变作用。病理组织学观察表明,实验烟组比对照烟组的损伤程度轻、波及范围小。结论低自由基香烟对大鼠气管及肺的病理影响较小,说明低自由基香烟更具有安全性。
Objective To study the effect of the low free radical cigarettes （test cigarettes） on the blood biochemical parameters, lung and polychromatophilic red cell micronucleus in rats. Methods 36 SD rats were randomly divided into the blank control group, the comparison smoke group and the experimental smoke group （low free radical cigarettes）, 12 in each. Let the rats smoke passively for 30 day, daily 12 cigarettes, then the determination of blood biochemical parameters and the polychromatophilic red cell micronucleus rate in the bone marrow, the pathological examination of the trachea and the lung tissues were conducted. Results Compared with the blank control, no significant changes were seen in the blood biochemical parameters and the polychromatophilic red cell micronucleus rate. The pathological examination of the lung tissues indicated that the pathological changes in the experimental smoke group were slight compared with the comparison smoke group. Conclusion No seriously adverse effects of low free radical cigarettes on the lung tissues of rats have been seen in the present study, that indicates that maybe the low free radical cigarette has an advantage in the health safety.
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2007年第7期529-532,共4页
Journal of Environment and Health
基金
云南省省院省校科技合作资金资助项目(2000YK-01)
关键词
烟草烟污染
自由基
血液生化指标
微核试验
呼吸系统
Tobacco smoke pollution
Free radicals
Blood biochemical parameter
Micronucleus tests
Respiratory system
