摘要
本研究利用高输入阻抗微电极放大器，观察正常豚鼠（ｎ＝３５）前庭壶腹嵴内电位（ＡＥＰ），以及缺氧、缺血、静脉注射速尿对其影响，探讨ＡＥＰ的电生理特性。结果表明正常豚鼠ＡＥＰ为４．５５±１．３５ｍＶ，停止呼吸机２ｍｉｎ，ＡＥＰ下降至２．３±０．８ｍＶ，恢复呼吸后均可观察到超射现象，阻断升主动脉后ＡＥＰ持续下降，达最大负值为－１９．４±１．７ｍＶ，所需时间为５２．５±９．６ｍｉｎ，约１５０ｍｉｎ后缓慢上升至０。静脉注射速尿后与注射前无显著差异。支持ＡＥＰ是不同于耳蜗内电位的正电位，有不同于耳蜗内电位的电生理特性。
The purpose of this paper is to understand the physiologic feature of the ampullar endolymphatic potential (AEP) in the guinea pigs (n=35). The high input impedence microelectrode amplifier was used. The effects of asphyxia, furosemide and ischemia on the AEP were observed. The AEP was 4 55±1 35mV, (n=35) in normal. The potential decreased to 2 8±0 8mV from the original level in two minutes of asphyxia. When the respirator was turned on the AEP started to rise abruptly after a latency. In all instances there was an overshoot above the preasphyxia level. When furosemide was administered i.v.at 100mg/kg, no effects were seen in the AEP. After obstruction of the ascending aorta to cause ischemia, the AEP continued to decline untill it reached a minimum of 19 4±1 7mV in 52 5±9 6 minutes and slowly returned to zero line in about 150 minutes. There was no obovious effect after furosemide injection. The results suggest that AEP may deffer from as the positive potential in cochlea. It is produced in the specialized cells (dark cells) of the ampullar and has special electro physiologic characterstics.
出处
《中国应用生理学杂志》
CAS
CSCD
1997年第3期246-248,共3页
Chinese Journal of Applied Physiology
关键词
前庭
壶腹嵴内电位
生理特性
电生理学
vestibule ampullar endolymphatic potential
asphyxia
ischemia
furosemide
