摘要
在无溶剂无催化剂微波辐射条件下，以3-取代基-4-氨基-5-巯基-1，2，4-三唑和芳香醛为原料合成了9种3-取代基-5-巯基-4-芳基亚氨基-1，2，4-三唑。将原料以等摩尔比混合，微波辐射3～10min，产率为81％-92％。产物的巯基未与亚氨基加成生成双杂环化产物。所得化合物结构经IR、^1H NMR测试技术得到确证。
Microwave-assisted synthesis of nine 4-arylideneamino-5-mercapto-3-substituted-4H-1,2,4-triazoles via the reaction of 4-amino-5-mercapto-3-substituent-1,2,4-triazoles with arylaldehydes under solvent-free conditions without catalyst was completed. The reactants were mixed in an equal molar ratio, and exposed to MW irradiation for 9 -10 min, and the yields were 81% -92%. The mercapto group did not react with the imine group to give the products with two heterocycles. This method avoids the long reaction time of usual synthesis route using ethanol as solvent and acid as catalyst, and saved the troubles of using acetic acid as solvent and catalyst. The structures of the products were confirmed by ^1H NMR and IR.
出处
《应用化学》
CAS
CSCD
北大核心
2008年第3期366-368,共3页
Chinese Journal of Applied Chemistry
基金
陕西省自然科学基金(2004B11)资助项目
关键词
无溶剂
无催化剂
微波辐射
取代基-巯基-芳基亚氨基三唑
solvent-free, uncatalyzed, microwave irradiation, arylideneamino-mercapto-substituted-triazoles
