摘要
目的研究ghrelin基因Arg51 Gln多态性在中国西安汉族人群的分布情况,并探讨该多态性与2型糖尿病、高血压病发病的相关性。方法应用PCR-限制性片段长度多态性法分析中国西安地区汉族人305例(正常对照组80例;2型糖尿病组125例;高血压病组48例;2型糖尿病合并高血压病组52例)Ghrelin基因Arg51 Gln多态性的分布及其与临床指标间的相关性。结果2型糖尿病组、高血压病组、2型糖尿病合并高血压病组的基因型频率分别与正常对照组相比,均无统计学意义(P值分别为:0.652、0.201、0.212);等位基因分布分别与正常对照比较无统计学意义(P值分别为:1.002、0.199、0.124);2型糖尿病组Gln51等位基因携带者的BMI、FINS、HOMA-IR均高于野生型(P值分别为:0.045、0.003、0.041)。结论该基因多态性与2型糖尿病胰岛素抵抗相关,Ghrelin基因Arg51 Gln多态性与高血压病无相关性。
Objective To investigate the distribution of Ghrelin gene Arg51Gln polymorphism from Chinese Han population in Xi＇an City and its association with type 2 diabetes mellitus or hypertension. Methods Ghrelin gene polymorphism was assayed by PCR-RFLP in 305 Chinese Hart subjects. Among them, there were 80 in normal control group, 125 in type 2 diabetes group, 48 in hypertension group, and 52 in type 2 diabetes＋ hypertension group. The relationship with clinical indexes was analyzed. Results The allele frequency and genotypes in type 2 diabetes group, hypertention group and type 2 diabetes＋ hypertention group were not significantly different from those in normal group （P = 0. 652, 0. 201, 0.212）. In the type 2 diabetes patients, BMI, FINS and HOMA-IR of the Gin51 carriers were significantly higher than those with the wild genotype （P = 0. 045, 0. 003, 0. 041）. Gonclusion The results suggested that polyrnorphism was associated with insulin resistance of type 2 diabetes. Arg51Gln polymorphism in the Ghrelin gene was not associated with hypertension.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2008年第1期80-83,共4页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
陕西省科技攻关基金资助项目(2002K10-G4)
