摘要
目的:观察灯盏花素注射液(breviscapine,Bre)对大鼠心肌缺血再灌注心律失常的保护作用。方法:结扎冠状动脉左前降支40min后复灌60min建立大鼠心肌缺血再灌注损伤模型,心电图监测心律失常情况和记录再灌注15min、30min、60min时ST段的变化值,并检测心肌组织超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量;测定血清中乳酸脱氢酶(LDH)含量。结果:Bre能明显降低再灌注心律失常的发生率,缩短心律失常持续时间,降低ST段的抬高程度;可减少血中LDH和心肌中MDA的含量,保护心肌SOD活性。结论:Bre对大鼠心肌缺血再灌注心律失常有保护作用,其机制与清除氧自由基,抑制脂质过氧化反应有关。
Objective ： To observe the protective effects of Breviscapine injection （ Bre ） on myocardial ischemia-reperfusion arrhythmia in rats. Methods： The myocardial ischemia-reperfusion model was induced by the ligation of left coronary artery for 40 min and followed by 60 min reperfusion. The changes of arrhythmia with electrocardiogram lead, superoxide dismutase （SOD） , malondialdehyde （MDA） in myocardium and lactate dehydrogenase （LDH） in blood serum were assayed. Results ： Bre could effectively prevent the incidence of reperfusion arrhythmias （ VT and VF） ,retard the appearing time and shorten the duration of arrhythmia, reduce the elevation of the ST segment as well. It decreased significantly the contents of MDA and LDH, and increase the myocardial SOD. Conclusion ： Bre has protective effect on myocardial ischemia-reperfusion arrhythmia in rats,which may be related to scavenging the oxygen free radicals and prevent the peroxidation.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2008年第1期33-34,共2页
Pharmacology and Clinics of Chinese Materia Medica
