期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脑梗死周围缺血半暗带的核素显像 被引量：2

Radionuclide Imaging of lschemic Penumbra Surrounding Cerebral Infarction
原文传递
导出
摘要 脑梗死周围存在缺血半暗带，缺血半暗带是卒中治疗的主要靶点。核索显像能通过对梗死灶周围组织的局部脑血流、代谢变化、^11C-氟马西尼受体显像和乏氧显像等方法有效检测缺血半暗带，为脑梗死的个体化治疗提供指导。 Ischemic penumbra exists in ischemic zone surrounding cerebral infarction, and ischemic penumbra is the major target in the treatment of stroke. Radionuclide imaging can effectively detecting ischemic penumbra through regional cerebral blood flow （rCBF）, metabolic changes, ^11C-flumazenil receptor imaging, and hypoxic imaging in the peripheral area surrounding infarction. It may provide a guide for the individualized treatment in patients with cerebral infarction.
作者 刘耿熙 杨友松
机构地区 四川省人民医院神经内科
出处 《国际脑血管病杂志》 2008年第1期26-30,共5页 International Journal of Cerebrovascular Diseases
关键词 脑梗死 半暗带 核素显像 cerebral infarction penumbra radionuclide imaging
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献22

  • 1Astrup J, Symon L, Branston NM, et al. Cortical evoked potential and extracellular K^+ and H^+ at critical levels of brain ischemia. Stroke, 1977, 8:51 -57.
  • 2Hakim AM. Ischemic penumbra: the therapeutic window. Neurology, 1998, 51(3 Suppl 3): S44 - S46.
  • 3Xia CF, Yin H, Borlongan CV, et al. Kallikrein gene transfer protects against ischemic stroke by promoting glial cell migration and inhibiting apoptosis. Hypertension, 2004, 43: 452 - 459.
  • 4Zheng Z, Zhao H, Steinberg GK, et al. Cellular and molecular events underlying ischemia-induced neuronal apoptosis. Drug News Perspect, 2003, 16:497 -503.
  • 5Liverman CS, Cui L, Yong C, et al. Response of the brain to oligemia: gene expression, c-Fos, and Nrf2 localization. Brain Res Mol Brain Res, 2004, 126:57 - 66.
  • 6Maulaz A, Piechovcski-Jozwiak B, Michel P, et al. Selecting patients for early stroke treatment with penumbra images. Cerebrovasc Dis, 2005, 20(Suppl 2): 19 -24.
  • 7Kidwell CS, Alger JR, Saver JL. Beyond mismatch: evolving peradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging. Stroke, 2003, 34:2729 -2735.
  • 8Xue M, Del Bigio MR. Intracortical hemorrhage injury in rats : relationship between btood fractions and brain cell death. Stroke,2000, 31:1721 -1727.
  • 9Heiss WD, Kracht LW, Thiel A, et al. Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia. Brain, 2001, 124:20 -29.
  • 10Koenig M, Kraus M, Theek C, et al. Quantitative assessment of the ischemic brain by means of perfusion-related parameters derived from perfusion CT. Stroke, 2001,32:431 -437.

二级参考文献16

  • 1刘生,王艺东,蒋宁一,陈少雄,邢诒刚.^(99)Tc^m-HL91 SPECT显像检测急性脑梗死乏氧脑组织的研究[J].中华核医学杂志,2004,24(4):236-237. 被引量：8
  • 2Read SJ,Hirano T,Abbott DF,et al.Identifying hypoxic tissue after acute ischemic stroke using PET and ^18F-fluoromisonidazole.Neurology,, 1998,51:1617 - 1621.
  • 3Song HC, Bom HS, Cho KH, et al. Prognostication of recovery in patients with acute ischemic stroke through the use of brain SPECT with Technetium-^99-labeled metronidazale. Stroke, 2003, 34:982 -986.
  • 4Guadagno JV,Donnan GA,Markus R,et al.Imaging the ischaemic penumbra.Curr Opin Neurol, 2004,17:61-67.
  • 5Heiss WD. Ischemic penumbra: evidence from functional imaging in man. J Cereb Blood Flow Metab, 2000, 20:1276 - 1293.
  • 6Olsen TS. Regional cerebral blood flow after occlusion of the middle cerebral artery. Acta Neurol Scand, 1986, 73:321 -337.
  • 7Kamada K,Houkin K,Iwasaki Y,et a.Metabolic and neurological patterns in chronic cerebral infarction:a single-voxel ^1H-MR spectroscopy study.Neuroradiology,1997,39:560-565.
  • 8Kim GE, Lee JH, Cho YP, et al. Metabolic changes in the ischemic penumbra after carotid endarterectomy in stroke patients by localized in vivo proton magnetic resonance spectroscopy (^1H-MRS). Cardiovasc Surg,2001,9:345 -355.
  • 9Furlan M,Marchal G,Viader F,et al.Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra.Ann Neurol,1996,40:216-226.
  • 10Mitsuaki Tatsumi,Kenji Yutani,Hideo Kusuoka,Tsunehiko Nishimura. Technetium-99m HL91 uptake as a tumour hypoxia marker: relationship to tumour blood flow[J] 1999,European Journal of Nuclear Medicine(2):91～94

共引文献16

同被引文献16

引证文献2

二级引证文献26

国际脑血管病杂志
2008年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部