摘要
目的观察爱维治(小牛血去蛋白提取物)防治急性放射性粘膜损伤的疗效。方法20例鼻咽癌患者随机分成两组:预防组10例(放疗+同期化疗+爱维治)及对照组10例(放疗+同期化疗)。放疗开始后均行常规口腔护理及鼻咽冲洗。观察急性放射性粘膜损伤出现的时间及按RGOT急性放射性口咽粘膜损伤分级及疼痛的VAS评分方法进临床评价[1]。所有中度以上患者同时给予静脉营养及补充维生素支持治疗,出现溃疡粘膜予以的卡因漱口及预防应用抗生素治疗。结果2组平均出现急性放射性粘膜损伤Ⅰ度的时间为放疗后23.2±12.2d及13.9±5.7d,两组比较有统计学差异(P<0.05)。预防组及对照组患者放射性粘膜反应呈Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级的分别占33.3%、55.6%、11.1%、0及0、30%、70%、0,两组比较有统计学差异(P<0.05)。预防组及对照组患者放疗后口咽部疼痛呈轻度、中度、重度分别占66.7%、22.%、0及10%、70%、20%,两组比较有统计学差异(P<0.05)。结论爱维治防治急性放射性粘膜损伤有明显的疗效,推迟了急性放射性粘膜炎产生的时间,并降低了放射性粘膜损伤的程度,减轻了口咽疼痛的程度,降低了因中断放射治疗导致疗程延长的概率。
Objective To evaluate the effect of Actovegin in the prevention of acute mucositis induced by radiotherapy.Methods 20cases with nasopharyngeal carcinoma were randomized into two groups：prevention .group （10 cases treated with chemoradiotherapy and actovegin） and control group （10 cases treated with chemoradiotherapy）.All patients were received daily regular oral cavity nursing and nasopharynx washing during irradiation courses.The time of occurring acute irradiation mucositis was recorded and it was evaluated according to the protocol proposed by RTOG.The pain degree was estimated using VAS.All patients were beyond midding-grade pain were received intravenous nutrition and intravenous infusion of vitamins,and patients with mucosal ulcer gargled with tetracaine or were used antibiotics to prevent infection.Results The time of occurring acute irradiation mucositis at stage I in prenvention group was later than in control group （23.2±12.2days VS l3.9±5.7days） and there was significantly difference between the two groups （P〈 0.05）.Mucosal injury at stage Ⅰ , Ⅱ, Ⅲ and Ⅳ in the two groups was occupied 33.3%,55.6%, 11.1%,0 and 0,30%,70% ,0 respectively,and there was also significanty difference between the two groups （P〈0.05）.The cases in prevention group and control group who were observed low-grade pain, midding-grade pain and high-grade pain occupid 66.7%, 22%, 0 and 10%, 70% ,20%respectively,and there was significantly difference between the two groups （P〈0.05）.Conclusion Actovegin has visible effect on prevention acute irradiation mucositis and may postponed the development of acute irradiation mucositis.h can also descrease the degree of mucosal injury,relieve the pain of oropharynx and decrease the probability of extending course of treatment by therapy interruption.
出处
《江西医药》
CAS
2008年第2期108-110,共3页
Jiangxi Medical Journal
关键词
爱维治
放射性粘膜损伤
鼻咽癌
放射治疗
Actovegin
iradiation mucositis
nsopharyngeal carcinoma
rdiotherapy
