摘要
目的探讨HIF-1a和VEGF表达与胃癌浸润和转移的关系。方法收集胃癌手术标本125例,应用免疫组化MaxvisionTM法检测HIF-1a和VEGF在胃癌组织中的表达。结果HIF-1a和VEGF的表达阳性率与肿瘤细胞分化及肿瘤大小无关,与肿瘤组织浸润深度、淋巴结转移、PTNM分期相关。HIF-1a和VEGF在胃癌组织中表达存在良好的一致性和相关性。结论HIF-1a和VEGF的阳性表达可作为预测胃癌转移潜能的生物学指标,且HIF-1a和VEGF的表达存在相关性,共同表达预示胃癌具有较强的侵袭转移能力,对于临床早期干预治疗具有重要的指导意义。
Objective To study the significance of the expression of HIF-1 a, VEGF protein in gastric carcinoma and to explore the correlation between the expression of HIF-1 a and VEGF protein. Methods The expression of HIF-1 a and VEGF protein was detected with MaxvisionTM immunohistochemical method in 125 patients with gastric carcinoma, Results There was no significant correlation between the HIF-1 a and VEGF protein expression and cancer size, cancer differentiation. Expression of HIF- 1 a and VEGF protein was significantly correlated with tumor invasion,lymph metastasis, and pathological TNM staging. There is a close correlation between the positive expression of VEGF and HIF-1 a protein. Conclusion HIF-1 a and VEGF protein are useful markers for predicting the metastatic potential of gastric cancer, The expression of HIF-1 a was correlated to that of VEGF. Expression of the two proteins suggests a more possibilities of tumor metastasis, and combined analyses of the two markers might be useful in the choice of treatment modalities.
出处
《实用癌症杂志》
2008年第2期135-137,共3页
The Practical Journal of Cancer
