摘要
目的:探讨MMP-9、PCNA在卵巢上皮性肿瘤中的表达和他们在卵巢上皮癌的浸润和转移中的作用。方法:选择临床病理资料齐全的卵巢上皮性肿瘤蜡块标本76例,利用S-P免疫组化方法检测MMP-9、PCNA在其中的表达。结果:两者在卵巢上皮癌组织中的阳性表达明显高于交界性、良性肿瘤,呈正相关(P<0.05);MMP-9在卵巢上皮性恶性肿瘤的表达与肿瘤的分化程度有显著相关性。结论:MMP-9、PCNA在卵巢上皮性肿瘤中的表达明显上调;MMP-9与卵巢上皮癌的浸袭、转移有关,可作为预测转移潜能的指标,PCNA可作为卵巢癌增殖的指标。
Objective： To investigate the expression of MMP-9 and PCNA in epithelial ovarian tumor and their effect in the invasion and metastasis of epithelial ovarian cancer. Methods： Selected 76 paraffin blocks of epithelial ovarian tumors with complete clinical pathological data, and used S-P immunohistochemistry to measure the expression of MMP-9 and PCNA in them. Results： Their positive expression rate in epithelial ovarian cancer were obviously higher than in boundary and benign tumors, showing positive correlation （P〈0.05） . The expression of MMP-9 in epithelial ovarian tumors was significantly correlative with the differentiated level of tumors. Conclusion： The expressions of MMP-9 and PCNA in epithelial ovarian tumor are obviously increased; MMP-9 is related to the invasion and metastasis of epithelial ovarian cancer, and it may serve as a predicting factor of metastasis potency; PCNA may serve as the factor of proliferation.
出处
《中国妇幼保健》
CAS
北大核心
2008年第7期975-977,共3页
Maternal and Child Health Care of China
