摘要
目的研究老年糖尿病和Ｘ综合征患者的胰岛素敏感性和心血管内分泌激素的关系，探讨老年糖尿病致发病的重要危险因素及相互关系。方法测定２１例老年糖尿病、２５例Ｘ综合征（Ｘ－ｓｙｎ）和２６例健康者的胰岛素敏感性、心钠素（ＡＮＰ）、内皮素（ＥＴ）、血管紧张素（ＡⅡ）、儿茶酚胺（ＣＡ）等，用美国ＳＡＳ软件作统计学处理，分析各组结果之间的差异和相互关系。结果发现糖尿病和Ｘ综合征组均存在胰岛素敏感性降低和ＡＮＰ、ＥＴ、ＣＡ、肾上腺素和去甲肾上腺素显著升高（Ｐ＜０．０５），后几项与胰岛素敏感性指数（ＳＩＳ）显著相关。Ｌｏｇｉｓｔｉｃ回归提示胰岛素敏感性降低、肥胖和血压升高是促发病的重要危险因素。结论在促使糖尿病和Ｘ综合征发病方面，胰岛素抵抗和心血管内分泌激素有协同作用，这可能是老年糖尿病发病的重要机制之一。
Objective To explore the relationship between IR and CE in elderly patients with NIDDM and X syndrome,and the relationship between the important pathogenic risk factors. Methods In 21 aged patients with NIDDM,25 with X syndrome and 26 normal controls,the insulin sensitive index(ISI, Ln(G×In)),ANP,ET,and CA,AⅡ et al were studied. The significance of differences were analyzed with SAS statistical software. Results all NIDDM and X syndrome groups had lower levels of SIS and higher levels of ANP,ET,CA,et al(all P <0 05).SIS was interrelated with ANP、ET、CA,et al.Logistic regression analyses showed that lower SIS,fat and increased BP were important risk factors in their pathogenesis. Conclusions In the promotion of pathogenesis of NIDDM and X syndrome,IR and CE may act synergistically.It may be one of the major mechanisms causing elderly NIDDM.
出处
《实用老年医学》
CAS
1997年第5期204-206,共3页
Practical Geriatrics
基金
安徽省科委立项资助
