摘要
目的观察化学修饰的四环素(米诺环素、多西环素)对全氟异丁烯(perfluoroisobutylene,PFIB)吸入性急性肺损伤的防治效果。方法采用小鼠动态吸入PFIB周身暴露染毒装置对实验小鼠进行染毒,观察了化学修饰的四环素(chemical modified tetracyclines,CMTs)给药组与中毒对照组小鼠的肺系数以及支气管肺灌洗液(bronchoalveo larlavage fluid,BALF)中蛋白质含量的变化情况。结果米诺环素预防可以显著性地降低各项肺系数以及减少BALF中蛋白质的含量;多西环素预防可以显著性地减少BALF中蛋白质的含量,多西环素治疗可以显著性地降低湿肺体比和干肺体比。结论CMTs药物米诺环素对PFIB吸入性急性肺损伤具有预防作用,而多西环素对PFIB吸入性急性肺损伤具有较弱的预防和治疗作用。
Objective To investigate the effects of chemical modified tetracyclines （minoeycline and doxycycline） on acute lung injury （ALI） induced by perfluoroisobutylene（PFIB） inhalation in mice. Methods ICR mice were exposed to gaseous PFIB in a flow-past whole-body exposure system. Lung toxicity and mortality induced by PFIB inhalation were studied. Results Minoeycline pretreatment （45 mg/kg, 20 rain before PFIB exposure） significantly reduced the lung index （wet/dry lung-to- body weight ratio, the water content in the lung and lung wet-to-dry weight ratio） and protein contents of bronchoalveolar lavage fluid（BALF） in ALI mice, while no effects were found when minoeycline （45 mg/kg） was administrated 1 h after PFIB inhalation. When doxycycline was valuated, it was observed that doxycycline （50 mg/kg） administrated 1 h after PFIB exposure could significantly lower the wet/dry lung-to-body weight ratio, and the same dose of doxycycline given 20 min before PFIB exposure could significantly reduce the protein content of BALF. Conclusion A preventive effects of minoeycline against the toxicity of PFIB inhalation was observed. A slight preventive and therapeutic effects of doxycycline against the toxicity of PFIB inhalation was observed.
出处
《中国职业医学》
CAS
北大核心
2008年第1期7-9,共3页
China Occupational Medicine
