摘要
目的探讨小剂量、短疗程和个体化的免疫抑制和(或)抗凝疗法治疗自身免疫型复发性流产(RSA)的安全性。方法2005年1月至2006年11月期间,在上海交通大学医学院附属仁济医院复发性流产专家门诊接受小剂量、短疗程和个体化的免疫抑制和(或)抗凝疗法治疗的自身免疫型RSA患者54例。对其中的34例的子代进行随访,其余16例失访。依据《诸福棠实用儿科学》测量方法对子代进行体格检查测量,采用首都儿科研究所按丹佛智能发育筛查法进行标准化的0～4岁小儿神经心理发育检查表(DDST)和中国20项新生儿行为神经测定(NBNA)评分法对子代进行智能筛查。结果发现子代在体格和智能发育上与我国15城市和九省市的资料相比较,差异无统计学意义。结论小剂量、短疗程和个体化的免疫抑制和(或)抗凝疗法,不仅是有效的,而且对RSA患者的子代是安全的。
Objective To investigate the safety of the individual therapy with low dose and short course of immune-suppression and anticoagulant for the offspring of the recurrent spontaneous abortion women with anticardiolipin antibody （ACA）. Methods From January 2005 to November 2006, there were 54 recurrent spontaneous abortion （RSA） patients with ACA receiving the individual therapy with low dose and short course of immune-suppression and anticoagulant. We had followed up the offspring of the 31 RSA patients, and the rest 16 RSA patients couldnt be connected with. We measured the physique of the offspring with the method of 〈 Zhu Fu-shang Practical Pediatrics 〉 and the intelligence of them with the DDST and NBNA method. Results There was no statistical difference in the physique and intelligence between the offspring of the RSA patients and the even-aged normal children in the fifteen cities and nine provinces of China. Conclusions The individual therapy with low dose and short course of immune-suppression and anticoagulant is not only effective for RSA with ACA but also safe for the offspring of the RSA patients.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2008年第3期192-194,共3页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
复发性流产
抗心磷脂抗体
免疫抑制
抗凝治疗
recurrent spontaneous abortion
anticardiolipin antibody
immune-suppression
anticoagulant therapy
