摘要
银屑病是一种复杂的多基因遗传病，有家族遗传倾向，但并非每个子代均发病。表观遗传是指DNA序列不发生变化但基因表达却发生可遗传的改变，它从以下3个层面上调控基因的表达：DNA甲基化、组蛋白修饰及非编码RNA调控（如RNA干扰），与遗传印记、X染色体失活等临床现象有关。肿瘤及多种自身免疫性疾病都有表观遗传学的改变。综述银屑病表观遗传学方面的研究进展，以探讨银屑病的发病机制。
Psoriasis is a disease of multifactorial inheritance, and not every member of offsprings of psoriasis patients would develop it. Epigenetics means inheritable changes in gane expression without any change in DNA sequence, and the expression of gene may be regulated via the following three mechanisms： DNA methylation, histone modification and noncoding RNA regulation （such as RNA interference）. Genetic imprinting and inactivation of X chromosome are associated with epigenetic inheritance. Epigenetic changes have been found in tumors and some autoimmune diseases. The author reviews the advances in epigenetic changes in psoriasis, which may benefit the elucidation of psoriasis pathogenesis.
出处
《国际皮肤性病学杂志》
2008年第2期98-100,共3页
International Journal of Dermatology and Venereology
