摘要
为了探讨洛铂与草酸铂分别与替加氟联合治疗晚期胃癌的效果，94例晚期胃癌患者分别接受方案A（32例）：替加氟（方克）800mg／m^2，持续24h静脉滴入，d1～d5；四氢叶酸钙（LV）200mg／m^2，2h静脉滴入，d1～d5；草酸铂（L-OHP）135mg／m^2，2h静脉滴入，d1；方案B（30例）：替加氟800mg／m^2，静脉滴入，d1～d5；LV和L-OHP的用法及用量同方案A；方案C（32例）：替加氟和LV用法及用量同方案A；LBP（洛铂）35mg／m^2，静脉滴入，d1。28d为1个周期。结果方案A：CR5例，PR16例，有效率65．6％；方案B：CR4例，PR16例，有效率66．7％；方案C：CR7例，PR16例，有效率71．9％；方案C优于方案A与方案B，差异无统计学意义，X^2=0．3284，P=0．849。三种方案的不良反应均易于接受。初步研究结果提示，替加氟分别与洛铂、草酸铂联合可以作为晚期胃癌安全有效的治疗方案。
In order to study the effect of lobaplatin or oxaliplatin combined with tegafur in the treatment of advanced gastric cancer, 94 cases of advanced gastric cancer were treated with regimen A （32 cases）., tegafur 800 mg/m^2 , CIV （24 h）, d1-d5 LV 200 mg/m^2 , ivgtt（2 h）, d1-d5 ;L-OHP 135 mg/m^2 ,ivgtt（2 h） ,d1; Regimen B （30 cases） ..tegafur 800 mg/m^2 ,ivgtt, d1- d5, LV 200 mg/m^2 , ivgtt（2 h）, d1- d5 ;L-OHP 135 mg/m^2 ,ivgtt（2 h）,d1 ; Regimen C （32 cases）., tegafur 800 mg/m^2 ,CIV （24 h）, d1-d5;LV 200 mg/m^2 ,ivgtt（2 h）, d--d5;LBP 35 mg/m^2 ,ivgtt,d1. The regimen were repeated every 28 days. There were 5 CR,16 PR cases in the regimen A; 4 CR,16 PR cases in the regimen B;7 CR,16 PR in the regimen C. The RRs of regimen A,B and C were 65. 6% ,66. 7% and 71.9% respectively. The difference did not reach the level of statistical significance, X^2 = 0. 328 4, P= 0. 849. The adverse effects of the three regimens were mild. In conclusion, the study of lobaplatin or oxaliplatin combined with tegafur in the treatment of advanced gastric cancer is safe and effective.
出处
《中华肿瘤防治杂志》
CAS
2008年第2期145-146,共2页
Chinese Journal of Cancer Prevention and Treatment
关键词
胃肿瘤/药物疗法
洛铂
草酸铂
替加氟
药物疗法
联合
stomach neoplasms/drug therapy
lobaplatin
oxaliplatin
tegafur
drug therapy, combination
