摘要
探讨缺铁性贫血（IDA）发病机理，为诊断、治疗、预后判断提供依据。用化学发光免疫分析法，对240例缺铁性贫血患者、30名对照者及112例IDA患者在对症治疗和口服力蜚能、生血宁治疗一个疗程（30天）前后，体内血清中促红细胞生成素（EPO）、叶酸（FA）、维生素B12（vit B12）、铁蛋白（Fer）水平变化及EPO／Fer、vit B12／FA比值的变化进行测定，并进行统计学分析。结果表明，缺铁性贫血组与对照组比较，EPO、FA、vit B12、EPO／Fer、vit B12／FA有显著性差异（P〈0．05～0．001），EPO、Fer水平及EPO／Fer比值变化在IDA患者治疗前后比较呈正相关（r=0．875，t=4．256，P〈0．001）。缺铁性贫血虽主要是由铁的供应和贮存铁缺乏引起，但与体内EPO、FA、Fer、vit B12水平变化密切相关，EPO、Fer水平及其比值变化与IDA的发生、发展、治疗和预后判断有一定关系，是诊断和鉴别IDA的重要指标。
To investigate the etiopathogenesis of iron deficiency anemia （IDA） for the evaluation of the diagnosis, therapy and prognosis of the disease, the serum levels of erythropoietin （EPO）, folic acid （FA）, vitamin B12 （vitB12）, ferritin （Fer） and the ratio of EPO to Fer and vitB12 to FA were measured by chemiluminescence immunoassay in 240 cases of IDA, 30 cases of normal control and 112 cases of IDA who take orally Niferex and Shengxuening for one month. The results showed that there was significant difference between patients and controls in the serum level of EPO,FA, vitB12,and the ratio of EPO to FA,vitB12 to FA （P〈0.05～0. 001）. There was positive correlation in the serum level of EPO,Fer and the ratio of EPO/Fer between pretreatment and post-treatment （r= 0. 875, t = 4. 256, P〈0. 001）. IDA was caused by the shortage of iron supply and storage, and was correlated closely with the variation of the serum levels of EPO, FA, Fer and vitB12. The changes of serum EPO, Fer levels and their ratios were related to the genesis, development, therapy and prognosis of IDA, which might be the important indications for the diagnosis of IDA.
出处
《标记免疫分析与临床》
CAS
2008年第1期20-22,共3页
Labeled Immunoassays and Clinical Medicine
关键词
缺铁性贫血
化学发光分析
促红细胞生成素
铁蛋白
Iron deficiency anemia
Chemiluminescence immunoassay
Erythropoietin
Ferritin
