摘要
观察中药舒郁散对慢性应激抑郁模型大鼠血清细胞因子的影响。将40只Wistar大鼠随机分为正常对照组、抑郁模型组、阿米替林组、舒郁散小剂量组、舒郁散大剂量组,每组8只大鼠,对照组每笼饲养4只,其它组每笼饲养1只。采用放射免疫分析法测定大鼠血清白介素2(IL-2)、白介素6(IL-6)和肿瘤坏死因子(TNF-α)的含量。结果表明:抑郁模型组动物血清IL-2、IL-6和TNF-α含量较正常对照组显著升高(P<0.05);中药治疗组和阿米替林组血清中IL-2、IL-6含量较抑郁模型组显著下降(P<0.05),中药治疗组与阿米替林组间比较无显著性差异。中药舒郁散对慢性应激性抑郁大鼠的细胞因子IL-2、IL-6和TNF-α具有调节作用,可下调升高的细胞因子发挥治疗抑郁症的作用。
To explore the serum levels of interleukin 2 （IL-2）, interleukin 6 （IL-6） and tumor necrosis factor α （TNF-α） on chronic stress depression rat model treated with traditional chinese herbs. 40 wistar rats were randomly allocated to 5 groups as follows, control group, depression model group, lower dosage Suyusan group, higher dosage Suyusan group and amitriptyline group. Each group had 8 rats. Each rat was raised in one cage except the control group, in which 4 rats were raised in one cage. The levels of serum IL - 2,IL - 6 and TNF-α were observed by radioimmunoassay. The results showed that compared with control group , the serum IL-2 ,IL-6 and TNF-α levels in depression model group increased significantly（P〈0.05） ; the serum IL-2,IL-6 levels in Suyusan group and amitriptyline group decreased, which had significant difference compared with those in depression model group（P〈0.05）. There was no significant difference between treatment group and control group. Conclusion. Suyusan decoction may regulate cytokine in the stressors induced depression rats, and maybe useful in depression treatment by decreasing cytokine which is high.
出处
《标记免疫分析与临床》
CAS
2008年第1期36-37,46,共3页
Labeled Immunoassays and Clinical Medicine
基金
国家教育部归国留学人员启动基金(No.2005-157)
关键词
中药
应激
抑郁症
细胞因子
Chinese herbs
Stress
Depression
Cytokine
