摘要
目的研究大肠癌患者血清可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）和肿瘤坏死因子（ＴＮＦ）变化的临床意义．方法采用双抗体夹心ＥＬＩＳＡ法对７６例大肠癌患者手术前后血清ｓＩＬ－２Ｒ和ＴＮＦ水平进行检测，其中根治性手术４８例，姑息性手术２８例，以４０例献血员为正常对照组．结果大肠癌患者血清ｓＩＬ－２Ｒ（Ｕ／Ｌ）和ＴＮＦ（ｐｇ／Ｌ）分别为６０３６±９４３和９６２±９１，明显高于正常对照组的２０８３±７９６和２５１±４７（Ｐ＜００１），两者的增高与大肠癌Ｄｕｋｅ分期及手术方式不同密切相关．结论动态观察血清ｓＩＬ－２Ｒ和ＴＮＦ的变化，可作为大肠癌诊断、评价疗效及监测预后的参考指标．
AIM To study the changes and the clinical significance of serum soluble interleukin_2 receptor (sIL-2R) and tumor necrosis factor (TNF) in colorectal carcinoma patients. METHODS Serum levels of sIL-2R and TNF were detected by the double antibody sandwich ELISA method in 76 colorectal carcinoma patients before and after operation and 40 normal donors served as controls. RESULTS The serum sIL-2R (603 6U/L±94 3U/L vs 208 3U/L±79 6U/L, P <0 01) and TNF (96 2pg/L±9 1pg/L vs 25 1pg/L±4 7pg/L, P <0 01) in colorectal carcinoma patients were significantly higher than that of healthy controls, while the serum sIL_2R and TNF of the patients with colorectal carcinoma were intimately associated with Duke′s stages and operational approaches. CONCLUSION Dynamic alterations of serum sIL-2R and TNF levels can be used as indicators of diagnosis, therapeutic efficacy and prognosis in patients with colorectal carcinoma.
关键词
大肠肿瘤
癌
受体
白细胞介素-2
肿瘤坏死因子
colonic neoplasms/immunology
rectal neoplasms/immunology
receptors, interleukin_2/metabolism
tumor necrosis factor/metabolism
