摘要
为了研究离断骨在一定应力状态下植入血管束后，能否重建骨的血液循环以及血管束移植对成骨的影响，作者将１８只成年杂种犬胫骨两端截断，切除实验骨区的骨膜，胫骨离断面填入硅胶膜以阻断两侧干骺端血供，将离骨段固定于原位；分离出胫前动静脉束并结扎。随机分成３组，实验Ａ组（ｎ＝７）：结扎后的血管直接植入骨髓腔；Ｂ组（ｎ＝７）：血管束打孔后植入骨髓腔；Ｃ组（ｎ＝４）：离断后的胫骨段内不植血管，作为对照。术后分别于不同时间进行血管造影、血管筑型、大体及组织学和电镜观察。实验结果显示：原实验骨因初期缺血均发生无菌性坏死；在一定应力状态下，血管束骨内移植后，植入的血管再生旺盛，骨髓腔内成骨活跃。结果表明，血管束骨内移植后可重建坏死骨的血液循环，膜性化骨和软骨内化骨在成骨因素中均发挥着重要作用。
To elucidate whether the revascularization of isolated bone could be built and what is the influence on osteogenesis. We studied eighteen adult mongrel dogs and divided them into three groups in random. Osteotomy was performed on the two condyles of the tibia and the periosteum was removed. Two pieces of silica gel sheet were inserted into the gaps of osteotomy to block blood supply, then immobolization was made. The vascular bundle of anterior tibia artery and vein was separated and ligated .Subseguently,at was directly implanted into the isolated bar of tibia(Group A, n =7).It implanted after holes were made (Group B, n =7).Controls (Group C, n =4) were observed without transplantation. The animals were investigated by angiography, casting mode of vascular net, mass and histologic and electromircroscopeic examination at different intervals.Osteonecrosis was occurred in the tested bone because of ischemia. The proliferation of vascular net was occurred and prosperous osteogenesis was found in the medullary cavity after transplanting a vascular bundle.Revascularization of necrotic bone was able to be established by transplanting a vascular bundle. Both membranous and lndochondral ossification play an important role in osteogenesis.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1997年第5期307-309,共3页
Chinese Journal of Surgery
