摘要
目的探讨2型糖尿病视网膜病变(DR)的危险因素。方法采用以医院为基础的成组病例-对照研究方法,使用统一的调查表对93例病例和194例对照进行问卷调查,并进行体格检查和实验室检查。采用Logistic回归模型对DR的危险因素进行单因素和多因素分析。结果单因素Logistic回归分析结果表明,糖尿病确诊年龄、糖尿病病程、调查时空腹血糖和餐后2h血糖、体质指数(BMI)、腰围、臀围与DR的发生有统计学意义,OR及其95%CI分别为0.963(0.935～0.991),1.424(1.084～1.871),1.088(1.008～1.174),1.140(1.065～1.220),0.641(0.453～0.905),0.963(0.938～0.988)和0.965(0.936～0.995)。但经调整可能的混杂因素的作用后,糖尿病确诊年龄、糖尿病病程、调查时餐后2h血糖、BMI、腰围和臀围与DR发生之间的联系仍有统计学意义,OR及其95%CI分别为0.966(0.938～0.995),1.374(1.041～1.815),1.130(1.042～1.226),0.688(0.483～0.980),0.966(0.942～0.992)和0.965(0.935～0.995),而调查时空腹血糖与DR发生之间的联系无统计学意义。未发现血糖控制情况、既往高血压史、糖尿病家族史、高血压家族史、心脏病家族史、高脂血症史、吸烟史、饮酒史、体育锻炼、性格、调查时血胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、极低密度脂蛋白和纤维蛋白原、腰臀比等与DR的发生之间有统计学意义。结论糖尿病确诊年龄小、糖尿病病程长均可增加DR发生的危险性;调查时餐后2h血糖水平高、BMI大、腰围和臀围大与较高的DR危险性有关。
Objective To explore risk factors for diabetic retinopathy （DR） in type 2 diabetic patients. Methods A hospital-based case-control study was conducted. Information of 93 cases and 194 controls was collected. The effects of the collected factors on the risk for the diabetic nephropathy development were examined using the logistic regression model Results The univariate logistic re- gression analysis showed that DR was associated with age at diabetes diagnosed, diabetes duration, fasting blood glucose level, blood glucose level at 2 hour postprandial, the body mass index （BMI）, waist and hip circumferences. Odds ratios （ORs） and their 95% confidence intervals （C/s） were 0.963 （0.935-0.991）, 1.424 （1.084-1.871）, 1.088 （1.008-1.174）, 1.140 （1.065-1.220）, 0.641 （0.453- 0.905）, 0.963 （0.938-0.988） and 0.965 （0.936-0.995）, respectively. However, after adjustment for possible confounding factors, significant associations only still existed between DR and age at diabetes diagnosed, diabetes duration, blood glucose level at 2 hour postprandial, BMI, waist girth and hip girth, the adjusted ORs and their 95% Cls were 0.966 （0.938-0.995）, 1.374 （1.041-1.815）, 1.130 （1.042-1.226）, 0.688 （0.483-0.980）, 0.966 （0.942-0.992） and 0.965 （0.935-0.995）, respectively, but the association between fasting blood glucose level and DR was not statistically significant. Conclusions The younger the age at diabetes diagnosed and the longer diabetes duration were, the higher the risk of developing DR was. High blood glucose level at 2 hour postprandial, BMI, waist circumferences and hip circumferences were associated with high risk for DR.
出处
《中国慢性病预防与控制》
CAS
2008年第1期20-22,共3页
Chinese Journal of Prevention and Control of Chronic Diseases
