摘要
目的探讨血清AT1、α1、β1、M2-受体自身抗体与高血压病肾损害的关系及干预治疗效果。方法检测58例高血压病肾损害患者、60例高血压病无肾损害患者、50例正常人AT1、α1、β1、M2-受体自身抗体及早期肾功能损害指标,高血压患者均给予氯沙坦治疗。结果肾损害患者血清AT1、α1、β1、M2-受体自身抗体阳性率明显高于无肾损害患者,氯沙坦降压作用明显,能显著改善肾功能。结论血清抗AT1、α1、β1、M2-受体自身抗体可能与高血压病肾损害有关,氯沙坦能降低血压,可减轻和延缓高血压病引起的肾损害。
Objective To explore the relation between the autoantibodies against angiotensin Ⅱ type 1 receptor（ATl -receptor）, α1 - adrenergic receptor（ α1 -receptor）, β1 -adrenergic receptor（β1 -receptor）, M2 -inuscarrinic receptor（M2-receptor） and hypertension with renal failure,and the effects of angiotensin Ⅱ receptor antagonist on the renal function in hypertension patients.Methods 58 patients with hypertension with renal failure, 60 patients with hypertension without renal failure and 50 healthy subjects were detected for ATI receptor,α1-receptor, β1-receptor and M2-receptor. All of the patients were given intervenient therapy with losartan. Results The positive rates of the autoantibodies against ATI receptor,α1 -receptor,β2 -receptor and M2-receptor of patients with renal failure were higher than than patients without renal failure Losartan significantly reduced the blood pressure in hypertensive patients after treatment. Losartan treatment evidently improved renal functions. Conclusion The findings strongly suggestted that these autoantibodies against AT1-receptor, α1-receptor,β1-receptor and M2-receptor may play important roles in the pathogenesis of hypertension with renal failure. Losartan shotdd be able to decrease blood pressure and improve renal function effectively.
出处
《医学综述》
2008年第5期791-793,共3页
Medical Recapitulate
