摘要
目的探讨EZH2基因在膀胱癌组织中的表达意义及其与临床病理的关系。方法半定量PCR法检测EZH2 mRNA表达，免疫组化SP法检测EZH2蛋白表达，分析其与临床病理特征的关系。结果肿瘤组织中EZH2 mRNA和EZH2蛋白的表达水平均明显高于正常移行上皮组织，并与临床分期、病理学分级有关：低分化肿瘤组织中EZH2表达高于高分化肿瘤组织（P〈0．05），浸润肿瘤EZH2的表达高于浅表肿瘤（P〈0．05）。结论膀胱癌组织EZH2基因表达增加与膀胱移行上皮细胞恶性生长及不良预后有关。
Objective To study the expression and clinical significance of EZH2 in transitional cell carcinoma of bladder,as well as its relationship with pathology. Methods The expression of EZH2 mRNA was detected by half-quantitive PCR. The expression was measured by SP immunohistochemistry. Results The expression of EZH2 mRNA and EZH2 protein in tumor tissue was higher than in the normal transitional epithelial tissue, which was related with clinical staging, pathology staging. The expression of EZH2 in low-differentiated tumor tissue was higher than that of highly-differentlated tissue（ P 〈 0.05 ）, which was higher in infiltrative tumor than in superficial tumor （P 〈0.05 ）. Conclusion Increased expression level of EZH2 in bladder tumor tissue is related with malignant growth of transitional epithelial cell of bladder and poor prognosis.
出处
《中国综合临床》
北大核心
2008年第3期193-195,共3页
Clinical Medicine of China
基金
国家自然科学基金资助项目（30371601）
关键词
膀胱癌
EZH2
增殖
Bladder carcinoma
Enhancer of zeste homolog 2
Proliferation
