摘要
目的:探讨血清抵抗素水平与2型糖尿病(T2DM)患者血管并发症的关系,及其可能在T2DM血管并发症中所起的作用。方法:选取40例T2DM患者,同时选取20例健康人作为对照组。受试者空腹采血,测定血清抵抗素、一氧化氮(NO)、血管性血友病因子(vWF);行OGTT并测定C肽、胰岛素及生化检查,同时测血压、身高、体重、腰围、体重指数、胰岛素敏感指数、胰岛素抵抗指数等。结果:T2DM患者血清抵抗素、vWF水平均高于正常对照组;NO低于正常对照组。T2DM组抵抗素与vWF呈正相关;与NO呈负相关。结论:T2DM患者血清抵抗素水平增高,且与血管内皮功能相关指标呈正或负相关,提示抵抗素可能与T2DM血管并发症的发生有关,是预测血管并发症的有价值的指标。
complications in type 2 Objective： To investigate the University et al between serum resistin levels and vascular diabetes mellitus （T2DM）. Methods ：Fasting serum and Willebrand factor （vWF）levels were measured in 40 cases of T2DM and 20 normal nitric oxide （NO）, von controls. OGTT was performed and C peptide, insulin were measured. Meanwhile the glycosylated hemoglobin, blood pressure, height,and weight were measured, and body mass index, insulin resistance and insulin B cell function were also examined. Results：The levels of serum resistin,vWF in type 2 diabetic patients were remarkably higher than those in control group ;the levels of serum NO were significantly lower in T2DM. A correlation analysis showed that the increased level was positively correlated with vWFand negatively correlated with NO. Conclusion;The resistin level in type 2 diabetic group was positively or negatively correlated with the index of vascular endothelial cell dysfunction, therefore resistin may be related to diabetic vascular complications,and may be avaluable indexe to predict diabetic vascular complications.
出处
《陕西医学杂志》
CAS
北大核心
2008年第3期312-313,共2页
Shaanxi Medical Journal
关键词
糖尿病
非胰岛素依赖型/并发症
@抵抗素
血管疾病/病因学
内皮
血管
Diabetes Mell disease/etiology Endothelium,vascular complications. itus non-insulin-dependent/complications @Resistin Vascular
