摘要
目的探讨单纯性乳房早发育(PT)向完全性中枢性性早熟(CCPP)转化的易患因素。方法纵向回顾分析广州中山大学附属第一医院1995—2005年确诊为PT的151例患儿临床及实验诊断资料。结果按转化将151例患儿分为CCPP转化组31例,非转化组120例。20.5%PT转化为CCPP,于年龄(7.07±0.65)岁,骨龄(8.97±1.12)岁时转化。又按乳房消退情况将患儿分为3组,105例(69.5%)初诊后乳房完全消退,31例(20.5%)乳房退缩后反复增大,15例(9.9%)乳房持续不退,3者分别有13.3%、32.3%、46.7%转化为CCPP,3组转化率差异有统计学意义(χ2=12.23,P=0.002)。结论PT并非都呈自限性,部分会转化为CCPP。与雌激素暴露相关的子宫长径、乳房Tanner分期和乳房消退情况是转化的危险因素,以后两者的风险值最大。
Objective To detect the risk factors for girls with premature thelarche （PT） converting into complete central precocious puberty （CCPP）. Methods To analy the follow-up databases of the clinical and sexual axis characteristics in 151 girls with PT diagnosed from 1995 to 2005 in the First Hospital Affiliated to Sun Yat：san University. Results A total of 31 （ 20. 5% ） patients with PT during follow-up converted into CCPP. The girls were （ 7.07± 0. 65 ） years of chronological age and （ 8. 97 ± 1.12 ） years of bone age when identified as having converted into CCPP. 69. 5% of them experienced complete regression of breast development＇ of whom fourteen （13.3%） converted into CCPP; 20.5 % had recurrent breast development, of whom ten （ 32. 3% ） converted into CCPP; 9. 9 % had constant breast size, of whom seven {46.7% ） converted into CCPP; there were statistically significant differences of the converting rate among the three groups. Conclusion PT is not always a self-limited condition and may partly convert into CCPP. The related factors to estrogen expoSition,including initial longitudinal diameter of uterus ,Tanner staging of breast and regressive stage of breast, may be the important risk factors of converting into CCPP,especially the later two factors.
出处
《中国实用儿科杂志》
CSCD
北大核心
2008年第3期174-176,共3页
Chinese Journal of Practical Pediatrics
