摘要
目的观察新冠心苏合滴丸对异丙肾上腺素(ISO)所致大鼠急性心肌缺血的保护作用。方法采用腹腔注射ISO方法复制大鼠急性心肌缺血模型,检测心电图(ECG)改变及心脏组织匀浆超氧化物歧化酶(SOD)活性、丙二醛(MDA)和一氧化氮(NO)含量以及血清谷草转氨酶(GOT)含量。结果新冠心苏合滴丸能明显降低血清GOT含量,提高心肌匀浆组织中NO含量、SOD活性,降低MDA含量,降低ECG异常的阳性率,与心肌缺血模型组比较有统计学意义(P<0.05,P<0.01)。结论新冠心苏合滴丸具有对抗ISO致大鼠急性心肌缺血的作用。
Objective To observe the effect of Xin Guanxin Suhe Drop Pill（XGSDP） on isoprenaline （ISO） - induced acute myocardial ischemia （AMI）. Methods Acute myocardial ischemia rats model were established by injection of ISO. Electrocardiogram （ECG） was observed, superoxide dismutase（SOD） activity, and the contents of malondialdehyde （MDA） and nitric oxide （NO） in the myocardial homogenate as well as serum and glutamate oxaloacetate transaminase （GOT） were observed after/SO injection. Results XGSDP could significantly increase NO content and SOD activity, decrease contents of MDA and GOT and reduce the positive rate of ECG （ P 〈 0. 05 or P 〈 0. 01 compared with the model group）. Conclusion Xin Guanxin Suhe Drop Pill has therapeutic effect on ISO - induced myocardial ischemia injury.
出处
《中药新药与临床药理》
CAS
CSCD
2008年第2期109-111,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
河北省科技厅攻关项目(0520611034D-15)
