摘要
目的探讨广州地区原发性肝癌患者的临床特点及病因。方法对215例原发性肝癌患者的临床资料如乙肝病毒（HBV）标记物、肝功能、肿瘤标记物甲胎蛋白（AFP）等进行分析。结果本组215例肝癌患者中40—59岁132例（61．4％），为高发年龄段。215例患者中HBsAg阳性176例（81．9％），伴肝硬化的肝癌患者160例（74．4％）。AFP≥20ng／dl者168例（78．1％），其中AFP≥500ng／dl者110例（51．2％）。谷丙转氨酶（ALT）升高者62．8％，谷草转氨酶（AST）升高者74．0％。γ-谷酰转肽酶（GGT）升高者70．7％。结论本地区原发性肝癌与HBV感染以及肝硬化密切相关。对乙肝表面抗原（HBsAg）阳性＋抗-HBe阳性＋抗-HBc阳性模式、年龄在40—59岁人群应定期体检对早发现原发性肝癌有重要意义。AFP用来诊断肝癌敏感性还待提高。
Objective To explore etiological factors and clinical characteristics of primary hepatic carcinoma （ PHC ） in Guangzhou area. Methods The clinical data such as HBV markers, hepatic functions, tumor markers as AFP etc. of 215 patients with primary hepatic carcinoma were analyzed. Results There are 132 patients （61.6%） with primary hepatic carcinoma in age range of 40 -59 years, and this is the high risk age range of PHC. One hundred and seventy - six （81,9% ） of 215 patients have positive serum HBsAg, and the number of patients with cirrhosis are 160 （ 74.4% ）. There are 168 patients （78.1%） with AFP≥20 ng/dl, and 110 （51,2%） of them with AFP≥500 ng/dl. The increased serum levels of ALT, AST and GGT are seen in 62, 8% ,74.0% and 70.7% of patients respectively. Conclusion In Guangzhou area, PHC has close correlation with HBV infection and cirrhosis. It is very important to carry out regular physical examination in people in age range of 40 -59 with positive HBsAg, anti - HBe and anti - HBc for early detection of PHC. Furthermore, the sensitivity of AFP in diagnosis of PHC needs further improvement.
出处
《临床和实验医学杂志》
2008年第3期11-12,共2页
Journal of Clinical and Experimental Medicine
基金
2006年度广州市医药卫生科技重大项目(2006-Zda-005)
关键词
肝癌
肝炎
肝硬化
Hepatocellular carcinoma
Hepatitis
Cirrhosis
