摘要
目的探讨阿托伐他汀对扩张型心肌病(DCM)合并心力衰竭患者血清肝细胞生长因子(HGF)水平的影响。方法扩张型心肌病合并心力衰竭患者共60例,随机分为常规治疗与加用阿托伐他汀组各30例,治疗4周前后分别查血清HGF浓度和心脏左室收缩末期容积及左室射血分数,同时选择20例正常对照组。结果血清HGF浓度在扩张型心肌病合并心力衰竭患者明显高于正常对照组差异有统计学意义(P<0.01),治疗4周后,阿托伐他汀组左室收缩末期容积减少及左室射血分数提高更显著,但差异无统计学意义(P>0.05)。结论扩张型心肌病合并心力衰竭患者血清HGF水平明显升高,短期阿托伐他汀可降低DCM患者的血清GHF浓度,该作用独立于其降血脂作用并与心功能的改善无关。
Objective To study the effects of atorvastatin treatment on HGF and left ventricular function in patients with chronic heart failure secondery to dilated cardiomyopathy （DCM）. Methods data from 60 patients were randomly divided into conventional therapy and plus atorvastain group,4 weeks after treatment. Results HGF levels in atorvastatin group significantly decreased P 〈 0. 01, but no significant changes in left ventricular end - systolic volume and ejection fraction raise between groups P 〉 0. 05. Conclusion Atorvastatin decreases HGF in HF patients with dilated cardiomyopathy, the role independent of their cholesterol.
出处
《中国实用医药》
2008年第8期64-66,共3页
China Practical Medicine
