摘要
目的观察FOLFOX4方案治疗晚期结直肠癌的临床疗效及不良反应。方法采用草酸铂(OXA)85mg/m2,静脉滴注2h,第1天;亚叶酸钙(LV)200mg/m2静脉滴注2h,第1~2天;5-氟尿嘧啶(5-FU)400mg/m2,第1~2天静脉注射;5-FU600mg/m2持续静脉滴注(22h)第1~2天的方案治疗30例晚期结肠癌患者。2周为1周期,重复4周期后间隔1个月评价疗效。结果全组30例,CR1例(3.3%),PR10例(33.3%),SD9例(30.0%),PD10例(33.3%),总有效率为36.6%。不良反应主要为神经毒性、胃肠道反应和骨髓抑制,多呈Ⅰ~Ⅱ度,可耐受。结论FOLFOX4方案治疗晚期结肠癌安全有效,可作为晚期结肠癌的首选化疗方案。
Objective To evaluate the efficacy and toxicity of the protocol of FOLFOX4 for advanced colorectal cancer. Methods 30 patients received FOLFOX4 [ Oxaliplatin 85 mg/m^2 as a 2-hour infusion on dayl and a 2-hour infusion of LV 200 rag/( m · d) followed by 5-FU bolus 400 mg/( m · d) and 22-hour infusion (600 mg/m · d)for 2 consecutive days every two weeks]. Four courses were carried out with an interval of one month. Results 30 patients:CR 1 case(3.3%),PR 10 cases(33.3%),SD 9 cases(30%),PD 10 cases (33.3%). The overall response rate was 36.6%. The major toxicities were neurotoxicity, suppression of bone marrow, gastrointestinal toxicity and most of which Ⅰ -Ⅱgrad. Conclusion The effective of FOLFOX4 which seems beneficial as first-line therapy in advanced colorectal cancer has a high effective rate with acceptable tox- icity.
出处
《中国现代药物应用》
2008年第4期14-15,共2页
Chinese Journal of Modern Drug Application