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铜绿假单胞菌耐药研究进展 被引量：20

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摘要 铜绿假单胞菌（PA）是假单胞菌中最常见的院内感染条件致病菌。目前临床分离率不断增加，逐渐成为医院感染监测细菌的重点，引起了人们的极大重视。其耐药性及耐药水平发展较快，已成为临床上重要的耐药菌之一。临床治疗十分困难，一旦感染，死亡率很高。
作者 施凯舜 潘发愤
机构地区 温州医学院附属第一医院感染科
出处 《浙江医学》 CAS 2008年第2期199-202,共4页 Zhejiang Medical Journal
关键词 铜绿假单胞菌 耐药水平 临床分离率 医院感染监测 院内感染 条件致病菌 临床治疗 耐药性
分类号 R446.5 [医药卫生—诊断学]
  • 相关文献

参考文献17

  • 1Chuanchuen R, Narasaki C T, Schweizer H P. The MexJ K efflux pump of Pseudomonas aeruginosa requires OprMfor antibiotic efflux but not for efflux of t riclosan[J]. J Bacteriol, 2002, 184 5036 - 5044.
  • 2Aendekerk S, Ghysels B, Cornelis P, et al. Characterization of a new effiux pump , MexGHI2OpmD,from Pseudomonas aeruginosat hat confers resistance to vanadium[J]. Microbiology, 2002, 148,2371 - 2381.
  • 3Li Y, Mima T, Komori Y. A new member of the tripartite multidrug efflux pumps, MexV W2OprM, in Pseudomonas aeruginosa [J]. J Antimicrob Chemother, 2003, 52:572- 575.
  • 4Akama H, Mat suura T, Kashiwagi S, et al, Crystal st ructure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa[J]. J Biol Chem, 2004, 279 (25):25939 - 25942.
  • 5Nikaido H. Multidrug efflux pumps of Gram- negative bacteria. J Bacteriol, 1996, 178(20): 5853.
  • 6Masuda N, Sakagawa E, Ohya S, et al. Subst rate specificities of MexAB-OprM, MexCD-OprJ, and MexXY2oprM efflux pumps in Pseudomonas aeruginosa [J]. Antimicrob Agent s Chemother, 2000, 44: 3322 - 3327.
  • 7李学如,孟涛,王艳.铜绿假单胞菌耐药机理研究进展[J].国外医药（抗生素分册）,2004,25(3):105-108. 被引量：115
  • 8Stover C K, Pham X Q, Erwin A L, et al. Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pat hogen[J]. Nature, 2000, 406:959- 964.
  • 9Aendekerk S, Ghysels B, Cornelis P, et al. Characterization of a new efflux pump, MexGHI -OpmD, from Pseudomonas aeruginosa that confers resistance to vanadium[J]. Microbiology, 2002, 148:2371 - 2381.
  • 10蒋晓飞,洪秀华,孙景勇,陈轶兰,倪语星.多重耐药铜绿假单胞菌超广谱β-内酰胺酶分析[J].中华微生物学和免疫学杂志,2002,22(4):443-446. 被引量：67

二级参考文献32

  • 1Heydom A,Ersboll B,Kato J,et al.Statistical analysis of Pseudomonas aeruginosa biofilm development:impact of mutations in genes involved in twitching motility,cell-to-cell signaling,and stationary-phase sigma factor expression [J].Appl Envir Microbiol,200
  • 2Bagge N,Ciofu O,Hentzer M,et al.Constitutive high expression of chromosomal β-Lactamase in Pseudomonas aeruginosa caused by a new insertion sequence located in ampD [J] Antimicrob Agents Chemother ,2002,46 (11):3406
  • 3Mac Gowan AP,Bowker KE.Mechanism of fluoroquinolone resistance is an important factor in determining the antimicrobial effect of gemifloxacin against Streptococcus pneumoniae in an in vitro pharrnacokinetic model [J].Antimicrob Agents Chemother ,2003,47 (
  • 4Kureishi A,Diver JM,Beckthold B,et al.Cloning and nucleotide sequence of Pseudomonas aeruginosa gyrA gene from strain PAO1 and quinolone-resistant clinical isolates [J].Antimicrob Agents Chemother ,1994,38 (9):1944
  • 5Takenouchi T,Sakagawa E,Sugawara M.Detection of gyrA mutations among 335 Pseudomonas aeruginosa stains isolated in Japan and their susceptibilities to fluoroquinolones[J].Antimicrob Agents Chemother ,1999,43(2) :406
  • 6Stove CK,Pham QX,Erwin AL,et al.Complete genome sequence of Pseudomonas aeruginosa PAO1 an opportunistic pathogen [J].Nature,2000,406:959
  • 7Poole K.Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria [J].Antimicrob Agents Chemother,2000,44 (9):2233
  • 8Masuda N,Ohya S.Cross-resistance to meropenem,cephems,and quinolones in Pseudomonas aeruginosa [J].Antimicrob Agents Chemother ,1992,36(9) :1847
  • 9Wong KK,Brinkman FS,Benz RS,et al.Evaluation of structural model of outer membrane protein OprM,an efflux component involved in intrinsic antibiotic resistance[J].J Bacteriol,2001,183(1) :367
  • 10Adewoye L,Sutherland A,Srikumar R,et al.The MexR repressor of the MexAB-OprM multidrug efflux operon in Pseudomonas aeruginosa:characterization of mutations compromising activity[J].J Bacteriol,2002 184 (15):4308

共引文献179

同被引文献148

引证文献20

二级引证文献91

浙江医学
2008年 第2期

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