摘要
哺乳动物SIRT1是酵母Sir2的同源基因,具有组蛋白去乙酰化酶活性,与细胞的增殖、分化、衰老、凋亡和代谢密切相关。SIRT1活性或表达量改变在心脏疾病的发生发展中起重要作用。SIRT1缺失使心脏发育异常,出生后存活率极低;SIRT1通过对P53、Bcl-2家族、脂肪细胞PPARγ等的调节,延缓冠心病、心力衰竭的发生和发展,此外,SIRT1通过对免疫细胞的调节,减轻心脏炎症。
The mammalian homolog Sir2（alpha） （SIRT1） is an NAD-dependent histone deacetylase that functions in proliferation, differentiation, aging, apoptosis and metabolism of cells in mammals. The decrease in SIRT1 is closely connected with pathologic hearts. Patients deficient in SIRT1 exhibit developmental abnormality in the heart and only infrequently survive postnatally. SIRT1 interacts with P53, Bcl-2 family, peroxisome proliferator-activated receptor-gamma （ PPARγ）, thus protecting the heart from coronary heart disease and heart failure. Furthermore, SIRT1 ameliorates myocarditis by its effects on the immune cells.
出处
《心血管病学进展》
CAS
2008年第2期323-325,共3页
Advances in Cardiovascular Diseases
基金
广东省自然科学基金重点项目(No.05008363)
