摘要
取代苯甲醛经缩合、催化氢化、环氧化和开环反应合成了9种2,2-二甲基-5-取代苯基-3-(1,2,4-三唑-1-基甲基)-3-戊醇类化合物和2种2,2-二甲基-5-取代苯基-3-(1,2,4-三唑-4-基甲基)-3-戊醇类新化合物.并对1,2,4-三唑-1-基衍生物和1,2,4-三唑-4-基衍生物的选择性合成进行了研究;新化合物结构经质谱,1HNMR,元素分析等确证,并用单晶X射线衍射测定了化合物1a的晶体结构.生物活性测试结果表明,部分化合物具有强杀菌活性.
Nine novel 2,2-dimethyl-5-（substituted phenyl）-3-（1,2,4-triazol-1-ylmethyl）pentan-3-ols and two novel 2,2-dimethyl-5-（substitutedphenyl）-3-（1,2,4-triazol-4-ylmethyl）pentan-3-ols were synthesized by condensation, hydrogenation, epoxidation and ring-opening reactions from substituted benzaldehydes. 1,2,4-Triazol-1-yl and 1,2,4-triazol-4-yl derivatives could be selectively synthesized under certain conditions. Their structures were clearly established by MS, 1H NMR spectra and elemental analysis. The crystal structure of compound la had been determined by X-ray diffraction analysis. The preliminary bioassays indicated that some compounds showed fungicidal activities.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2008年第3期443-448,共6页
Chinese Journal of Organic Chemistry
基金
国家科技支撑计划(No.2006BAE01A01-4)资助项目
关键词
三唑
合成
生物活性
晶体结构
triazole
synthesis
biological activity
crystal structure
