摘要
目的探讨青藏铁路沿线青海省境内鼠疫菌株生物学特点。方法对2001—2006年青藏铁路沿线青海省境内分离的鼠疫菌株进行生物学表型鉴定及分子生物学研究。结果所有被试菌株其生物型为古典型，生态型均为青藏高原型。大质粒65×10^6菌株主要分布于格尔木唐古拉乡地区。而质粒52×10^6菌株主要分布于天峻、德令哈地区：除乌兰县铜普乡大南湾地区的2株菌携带65×10^6大质粒外．该县其他地区分离的菌株均携带52×10^6质粒。格尔木市唐古拉乡地区的菌株基因型均为5型、德令哈市宗务隆地区及乌兰县赛什克乡、柯柯镇、铜普乡的菌株为8型，但有2株乌兰县铜普乡大南湾五沟白旱獭和患者体内分离的菌株为15型。结论该地区分离的鼠疫菌株均属青藏高原型，鼠疫菌的毒力强。
Objective To study the features of Yersinia pestis （ Y. pestis ） in areas along Qinghai-Tibet Railroad in Qinghai Province. Methods To identify the biologic types and the molecular biological feathers of Y. pestis isolated from areas along Qinghai-Tibet Railroad in Qinghai from 2001 - 2006. Results All the tested Y. pestis was biologically of classical type and ecologically of Qinghai-Tibet plateau type. The Y. pestis had high virulence. The Y. pestis of 65×10^6 plasmids was distributed in the Tanggula area, the Y. pestis of 52×10^6 plasmids, in Tianjun and Delingha areas. The Y. pestis srains carried 52 × 10^6 plasmids, except the two containing 65 ×10^6 plasmids in Wulan County. The genetic type of Y. pestis in Tanggula was type 5 and that in Zongwulong of Delingha, Saishike, Keke, Tongpu of Wulan was type 8 except 2 strains of Y. pestis isolated from woodchuck and the patients in Dananwan of Tongpu, Wulan County were type 15. Conclusion The Y. pestis in the area along Qinghai-Tibet Railroad in Qinghai belongs to Qinghai-Tibet plateau type with high virulence.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2008年第2期204-206,共3页
Chinese Jouranl of Endemiology
基金
“十五”国家科技攻关计划课题（2004BA718808）
