摘要
目的:评价济川煎对老龄大鼠胃肠蠕动的影响,并探讨其相关机制。方法:用小肠碳末推进试验观察济川煎对大鼠胃肠蠕动的影响;用放射免疫分析法检测大鼠小肠组织胃动素(MTL)、P物质(SP)和生长抑素(SS)的水平。结果:3.2,4.5 g.kg-1济川煎组大鼠小肠碳末推进率明显高于老龄组(P<0.05,和P<0.01);3.2,4.5 g.kg-1济川煎组大鼠小肠组织中MTL含量明显高于老龄组(P<0.05);1.6,3.2 g.kg-1济川煎组大鼠小肠组织中SP含量明显高于老龄组(P<0.01);1.6,3.2,4.5 g.kg-1济川煎组大鼠小肠组织中SS含量明显低于老龄组(P<0.05,和P<0.01)。结论:济川煎能增强老龄大鼠的胃肠蠕动功能,其机制可能与促进肠道胃动素、P物质的释放,降低肠道生长抑素水平有关。
Objective ： To investigate the effect of Jichuanjian on gastrointestinal peristalsis of senile rats and study relevant mechanism. Methods ： The effect of Jichuanjian on gastrointestinal peristalsis of senile rats was observed by small intestine charcoal powder propelling test. The levels of motilin, substance P and somatostain in small intestine of rats were detenninated by radioimmunoassay. Results： Different dosage of Jichuanjian can improve gastrointestinal peristalasis of senile rats and increase the levels of motilin, substance P, with reduce the content of somatostatin in small intestine of senile rats significantly. Conclusions ： Jichuanjian can＇ enhance the function of gastrointestinal peristalsis of senile rats by a mechanism of promoting secretion of motilin, substance P and lowering the level of somatostatin in intestine.
出处
《中国实验方剂学杂志》
CAS
2007年第11期44-46,共3页
Chinese Journal of Experimental Traditional Medical Formulae
