摘要
目的：用相对客观的标准比较单次注射、两种剂量的放射性核素姑息治疗骨转移癌性痛疼的效果及副作用。材料与方法：经多中心协作，７３例接受１５３Ｓｍ－ＥＤＴＭＰ注射，３７ＭＢｑ／ｋｇ或１８．５ＭＢｑ／ｋｇ两种剂量，从止痛剂用量、主观感觉、功能改善、化验及临床等，连续观察１６周进行比较。结果：两种剂量的止痛效果、止痛时间、副作用类型及程度等无差别，总止痛效率８６．３％；疗效持续时间为８．２±４．５周；５０％病例有血相改变，１０例有肝功改变；副作用均在４～６周内恢复；１０例无效。结论：单次１５３Ｓｍ－ＥＤＴＭＰ注射是有效的骨痛姑息治疗技术；疗效与副作用均与剂量无关；１５３Ｓｍ－ＥＤＴＭＰ治疗转移癌性骨痛，需要进一步客观、科学评价。
Purpose: In order to better understand 153 Sm EDTMP palliative treatment for bone pain caused by metastasis, multi center study sponsored by IAEA was organized. Materials and Methods: 73 cases of painful metastases from various primaries were given single injection of 153 Sm EDTMP introvenously in dosage of 37MBq/Kg or 18.5MBq/Kg. Evaluation of the efficacy and theside effects were based on a 16 week follow up. The symptom, general condition and change of analgestics were carefully recorded, so was the lab findings. Results: The total response rate after single dose of 153 Sm EDTMP was 86.3%. The effect persisted for 8.2±4.5 weeks, and was dosage independent, 50% showed blood count changes, 10 cases had evidence of liver damage. All side effects disappeared at 6 to 8 weeks. 9/10 nonreponding cases were male, 6 of them suffered from lung cancer. Conclusion: Single injection of 153 Sm EDTMP is effective in treating painful bone metastasis; the efficacy and side effects were both dosage independent; more well designed, deeply insighted study is justified to further understand radionuclide palliative therapy.
出处
《中国医学影像学杂志》
CSCD
1997年第3期129-131,共3页
Chinese Journal of Medical Imaging
基金
国际原子能机构区域合作计划
