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肿节风与氟尿嘧啶联合应用的抗肿瘤作用 被引量:11

The Anti-tumor Function of Zhongjiefeng United Fluorouracil
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摘要 目的:研究肿节风注射液与氟尿嘧啶(5-Fu)联合应用对小鼠移植性肝癌H22实体瘤生长的抑制作用。方法:建立小鼠H22实体瘤模型。小鼠60只,随机分为6组:正常对照组、肿节风注射液小剂量组(1.5g/kg,ip)、大剂量组(3g/kg,ip)、5-Fu组联合用药组。小鼠接种24h后开始给药,每天1次,连续10d。观察各组小鼠移植瘤生长情况及体重变化。并考察给药后胸腺、脾脏指数、外周血象的变化。结果:肿节风注射液小剂量组抑瘤率为26.84%,肿节风注射液大剂量组抑瘤率为44.74%,5-Fu组抑瘤率30.77%,联合用药组抑瘤率分别为58.39%与65.16%,与正常对照组比较,均有显著性差异(P<0.01);联合用药组抑瘤率高于单用肿节风注射液组和5-Fu组(P<0.01)。且联合用药对胸腺、脾脏指数、外周血象无明显影响。结论:肿节风注射液和5-Fu联用对小鼠移植性肝癌H22实体瘤有协同抗肿瘤作用,并能减轻5-Fu的毒副作用。 Objective: to investigate the depressant effect of zhongjiefeng injection and 5 - Fu on mouse transplanting hepatoma H22 solid tumor. Method: the mouse H22 solid tumor model was found and the mouse was divided 6 groups as follow: control, small dose zhongjiefeng injection (1.5 g/kg, ip), large dose (3 g/kg, ip), 5 - Fu group. The mouse was beginning fed drugs after inoculating 24 hours. The mouse-transplanted tumor growth and body weight, thoracic gland index and spleen index and the peripheral blood were observed in the test. Result: the depressant tumor rate was 26.84% in the small dose zhongjiefeng injection, 44.74 % in the large dose,30. 70% in the 5 - Fu group and 58.39% and 65.16% in the united drugs. There were significant difference with control (P〈0.01). There were not effect to thymus gland and spleen index and peripheral hemogram in the united drags. Conclusion: zhongjiefeng injection united 5- Fu had the cooperating anti-tumor function to mouse-transplanted H22 solid tumor.
机构地区 江西中医学院
出处 《河南中医学院学报》 2008年第2期30-32,共3页 Journal of Henan University of Chinese Medicine
基金 江西省中小企业创新基金项目(编号:06C26213601358)
关键词 肿节风注射液 氟尿嘧啶 肝癌H22实体瘤 抑瘤率 zhongjiefeng injection fluorouracil hepatoma H22 solid tumor restrain tumor rate
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