摘要
粒细胞集落刺激因子(G-CSF)是一种促粒细胞增殖的细胞因子,主要应用于各种原因引起的粒细胞减少症。近年来大量国内外的基础及临床研究表明,G-CSF能够动员骨髓间充质及外周血中的造血干细胞,在干细胞移植领域中为干细胞的释放、富集、动员、促进迁移、诱导分化等一系列问题的解决提供了一种新思路。本文旨在对G-CSF在干细胞移植领域中的新进展进行综述。
Granulocyte colony-stimulating factor （G-CSF） is a granulocyte lineage. It can be used to treat different kinds of gran specific hematopoietic regulating growth factor of ulocytopenia. Recently a variety of basic and clinical researches reported that G-CSF can mobilize bone marrow stem cells and haemopoietic stem cells in the peripheral blood, which suggested a potential aproach of releasing, enriching, mobolizing, promoting migration and inducing cell differentiation in the stem cell transplantation. The recent application of G-CSF in stem cell transplantation is reviewed in this view.
出处
《基础医学与临床》
CSCD
北大核心
2008年第3期289-293,共5页
Basic and Clinical Medicine
基金
黑龙江省自然科学基金(D200536)
关键词
粒细胞集落刺激因子
干细胞移植
granulocyte colony-stimulating factor
stem cell transplantation
