摘要
目的:探讨山西汉族类风湿关节炎(RA)与HLA-DPB1基因相关性。方法:用聚合酶链反应-序列特异性引物(PCR-SSP)方法检测36例RA患者和36例健康人的HLA-DPB1基因型。结果:RA患者HLA-DPB1*2201等位基因的频率显著高于正常对照组。结论:HLA-DPB1*2201可能是山西汉族类风湿关节炎的易感基因。
Objictive ： To investigate the association between HLA - DPB 1 and rheumatoid arthritis （RA） of the Han nationality in Shanxi. Methods：polymerase chain reaction - sequence specific primers （PCR - SSP） was used to study the HLA - DPBlgene in 36 patients with RA and 36 healthy controls of the Han nationality in Shanxi. Results： The allele frequencies of HLA - DPB 1 ＊ 2201 was significantly higher in RA patients than those in healthy controls. Conclusion ：Our date suggested that the HLA - DPB1 ＊ 2201 may be related to rheumatoid arthritis.
出处
《长治医学院学报》
2008年第1期24-26,共3页
Journal of Changzhi Medical College
基金
山西高校科技研究开发项目(20051318)
