摘要
目的探讨新一代质子泵抑制剂埃索美拉唑对反流性食管炎（RE）的临床疗效。方法将80例经内窥镜证实的RE患者随机分为两组。治疗组40例，给予埃索美拉唑20mg／次，每日2次；对照组40例，给予法莫替丁20mg／次，每日2次。疗程均为4周，两组同时加用促动力剂莫沙必利5mg做，每日3次。治疗结束后，记录烧心、反酸和胸骨后灼痛症状缓解率和胃镜复查总有效率。结果症状缓解的总有效率治疗组为92．5％，对照组为62．5％，两组差异有统计学意义（P〈0.05）；胃镜复查总有效率治疗组为82．5％，对照组为55．0％，两组差异有统计学意义（P〈0．05）。结论埃索美拉唑治疗反流性食管炎安全有效。
Objective To investigate the therapeutic effect of esomeprazole,a new type of proton pump inhibitor（PPI） ,on patients with reflux esophagitis（RE）. Methods 80 cases with RE diagnosed by endoscope were randomly divided into treatmcat group（ n = 40） and control group（ n = 40）. The treatmcat group was treated with esomeprazole 20 mg bid,compared with the control group famotidine 20rag bid. The two courses of treatment both persisted for four weeks and included mosapride 5mg rid. At the end of therapy, the rate of relief of heartburn,acid reflux and substernal burning symptom,and the total effective rate confirmed by endoscope were recorded. Results The clinical symptoms relief rates were 92.5 % in the treatment and 62.5 % in the control group respectively and had obviously statistical difference（ P 〈 0.05 ）. The total effective rate was confirmed by endoscope were 82.5 % and 55.0% respectively in two groups（ P 〈 0.05）. Conclusion Esomeprazole is a type of effective drug for patients with RE.
出处
《中国基层医药》
CAS
2008年第2期192-193,共2页
Chinese Journal of Primary Medicine and Pharmacy
