摘要
高效液相色谱法测定曲咪新乳膏中醋酸曲安奈德的含量。采用岛津Shimpack VP-ODS C18为色谱柱，以甲醇-水（60：40）为流动相，流速1．0mL·min^-1，二极管阵列检测器于485nm测定，柱温：28℃。醋酸曲安奈德线性范围为9．81～49．05μg·mL^-1（r=0．9998），平均回收率为98．4%，RSD为0．94％（n=6）。样品溶液在12小时内稳定。本法简便、快速、结果准确、可靠、重现性好，能有效地控制曲咪新乳膏的质量。
To determination of the content of triamcinolone acetonide acetate in Triamcinolone Acetonide Acetate and Miconazole Nitrate and Neomycin Sulfate Cream by HPLC. The column. Shimpack VP-ODS C18; The mobile phase, methanol-water （60 ： 40）; The flow rate： 1.0 mL ·min^-1; The detection wavelength was 485 nm. The chromatography was operated at 28℃. The linear response range were 9. 81449. 05 μg ·mL^-1 for triamcinolone acetonide acetate （r=0. 9998）. The average recovery was 98. 4%, RSD was 0. 94% （n= 6） . The sample solution was steady within 12h. The method is simple, rapid, accurate and suitable for determination of triamcinolone acetonide acetate in Triamcinolone Acetonide Acetate and Miconazole Nitrate and Neomycin Sulfate Cream.
出处
《中国药事》
CAS
2008年第3期237-239,共3页
Chinese Pharmaceutical Affairs
关键词
曲咪新乳膏
醋酸曲安奈德
HPLC
含量
Triamcinolone Acetonide Acetate and Miconazole Nitrate and Neomycin Sulfate Cream
triamcinolone acetonide acetate
HPLC
content
