摘要
本文建立Ｃ５７ＢＬ／６小鼠荷瘤动物模型，通过给荷瘤小鼠腹腔注射空白脂质体、单纯ＩＬ－２及ＩＬ－２脂质体来比较其在肿瘤生长中的抑制作用。结果是空白脂质体组抑瘤率为４．２６％，单纯ＩＬ－２和脂质体ＩＬ－２的抑瘤率分别为３４．０４％和５４．６０％。空白脂质体组与单纯对照组相比无显著性差异（Ｐ＞０．０５），脂质体ＩＬ－２组与单纯ＩＬ－２组之间存在显著性差异（Ｐ＜０．０５），脂质体ＩＬ－２的抑瘤率比单纯ＩＬ－２抑瘤率提高了２０．６％。
Human recombinant interleukin 2(IL 2) was encapsuloted in liposomes by reverse phase evaporation with an encapsulation efficiency of 34.5% ± 1.1% , and the antitumor effects of the liposomes containing IL 2 were studied using the C 57 BL/6 mice with louis lung carcinoma as an experimental model. The iv injection of IL 2 liposomes (533u·g -1 for the IL 2 dose) significantly inhibited the tumor growth as determined from the mean tumor weight ( P < 0.05 ). The inhibition rate of IL 2 liposomes was increased by 20.6% compared with free IL 2.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1997年第8期361-363,共3页
Chinese Journal of Hospital Pharmacy
关键词
白细胞介素-2
脂质体
抑瘤率
interleukin 2, liposome, inhibition rate of tumor
