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重组人Ⅱ型肿瘤坏死因子α受体抗体融合蛋白对肺纤维化鼠干预作用的实验研究 被引量：4

Experimental study on the effects of Ⅱrecombinant human α receptor antibody fusion protein of tumor necrosis factor in rats with pulmonary interstitial fibrosis
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摘要 目的探讨重组人II型肿瘤坏死因子α受体抗体融合蛋白(rhRPTN,免疫球蛋白)对肺间质纤维化鼠的干预作用。方法在给药后第7、21、28和42天,用放射免疫法检测治疗组、模型组和正常组血清中透明质酸、III型前胶原的含量以及大鼠的大体病理形态。结果大体肉眼观察大鼠肺组织的病理形态,治疗组改变较正常组和模型组轻,其透明质酸和III型前胶原含量较后2组亦低(P<0.01),有统计学意义。结论rhRPTN对肺间质纤维化的发生发展具有显著抑制作用。 Objective To study the intervention of Ⅱ recombinant human α receptor antibody fusion protein of tumor necrosis factor （rhRPTN） in rats with pulmonary interstitial fibrosis. Methods Detect the level of hyaluronic acid and Ⅲ precollagenous in rats blood serum in the 7th ,21st,28th,42nd days after ip rhRPTN. Results The level of the hyaluronic acid and Ⅲ prec lower than the normal and model monary tissues histopathology in and model groups. Conclusion ollagenous in trial （rhRPTN） group is groups （P 〈0.01 ）. The change trial group was lighter than the of pulnormal rhRPTN can inhibit the change of pulmonary interstitial fibrosis in rats.
作者 杨俊玲 林庆艳 赵令君 孙中美
机构地区 吉林大学第二临床医院呼吸内科 吉林大学第二临床医院放免实验室
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2008年第2期130-133,共4页 The Chinese Journal of Clinical Pharmacology
关键词 肺间质纤维化 重组人Ⅱ型肿瘤坏死因子受体抗体融合蛋白 pulmonary interstitial fibrosis Ⅱ recombinant human α receptor antibody fusion protein of tumor necorsis factor （rhRPTN）
分类号 R563 [医药卫生—呼吸系统] R974.3 [医药卫生—药品]
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参考文献13

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共引文献6

同被引文献55

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引证文献4

二级引证文献9

中国临床药理学杂志
2008年 第2期

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