摘要
目的：探讨乳腺癌HER-2表达与患者年龄和腋淋巴结情况的关系。方法：采用免疫组化SP法对3994例乳腺癌患者进行ER、PR、HER-2、p53和PCNA检测。中位随访时间42个月。结果：HER-2过表达阴性（-）2930例（73．4％），阳性1064例（26．6％），其中弱阳性（＋＋）621例（15．5％），强阳性（＋＋＋）443例（11．1％）。HER-2过表达在腋淋巴结阴性者中占24．3％，在腋淋巴结阳性者中占29．6％，其中1～3个淋巴结阳性者中占27．3％，4～9个淋巴结阳性者中占32．9％，〉10个淋巴结阳性者中占33．7％。HER-2表达与年龄呈负相关，P=0．035；与腋淋巴结转移数目呈正相关，P=0．001。HER-2表达与局部复发和区域转移无关，与远处转移呈正相关，P=0．006；腋淋巴结状况与复发转移呈正相关，P=0．001；年龄与复发转移无关。结论：年龄和腋淋巴结转移情况是HER-2表达的独立影响因素，HER-2过表达患者发生远处转移的危险性相对增高。
OBJECTIVE： To observe the relationship between HER-2 expression and age and axillary lymph nodes status in breast cancer. METHODS： Expressions of ER,PR, HER-2,p53 and PCNA were measured by immunohistochemistry （IHC）. The median follow-up time was 42 months. RE- SULTS： HER-2 was overexpressed in 1 064 cases （26.6%）, with （＋＋） 621 cases （16.6%） and （＋＋＋） 443 cases 11.1%. HER-2 overexpression was 24.3% in node-negative and 29.6% in node-positive cases, and among the node-posi- tive cases, node-positive from 1 to 3 being 27.3%, node-posi- tive from 4 to 9 being 32.9%, and node-positive over 10 being 33.7%. The expression of HER-2 was positively correlated with axillary lymph nodes status （P= 0. 001）, and negatively correlated with age （P=0.036）. HER-2 had no correlation with tumor recurrence and regional-metastasis, but positive correlation with distance-metastasis （P = 0. 006）. CONCLUSIONS： Axillary lymph nodes status and age could be taken as independent factors for HER-2 overexpression. HER-2 overexpression has potential influence on distance-metastasis.
出处
《中华肿瘤防治杂志》
CAS
2008年第6期447-449,共3页
Chinese Journal of Cancer Prevention and Treatment
