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PTEN在子宫内膜样腺癌中的表达及其临床意义 被引量：2

Expression of PTEN in endometrial carcinoma and its clinical significance
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摘要 目的:了解不同病理指标下抑癌基因PTEN(Phoshatase and tensin homology deleted on chromosome ten,PTEN)在子宫内膜样腺癌中的表达,探讨其与子宫内膜样腺癌的关系及其临床意义。方法:运用免疫组织化学方法测定PTEN在40例子宫内膜样腺癌、10例非典型增生子宫内膜和10例正常子宫内膜中的表达。结果:子宫内膜样腺癌标本中PTEN阳性染色率为55.00%,正常子宫内膜标本中PTEN阳性染色率为100.00%。但子宫内膜样腺癌中PTEN的表达与临床分期、肌层侵润深度、组织学分级及有无淋巴结转移等无明显相关性。结论:PTEN在子宫内膜样腺癌中有明显丢失现象,其在子宫内膜样腺癌早期发病中有着重要作用。 Objectives：To study the expression of PTEN in endometrial carcinoma under different pathological factors and to discuss its relationshipwith the occurrence of endometrial carcinoma and the clinical significance. Methods：The expressions of PTEN in 40 cases of endometrial carcinoma, 10 cases of atypical hyperplasia and 10 cases of normal endometria were examined by immunohistochemical method. Result：The positive staining rate of PTEN in endometrial carcinoma was 55.00%,and that in normal endometria was 100.00%. There was no obvious correlation between the expression of PTEN in endometrial carcinoma and different pathological factors such as clinical staging, depth of myometrial invasion and lymph node metastasis. Conclusion：The expression lack of PTEN exists in endometrial carcinoma,and PTEN has an important role in the occurrence of endometrial carcinoma.
作者 周勤 刘睿倩
机构地区 重庆医科大学附属第一医院妇产科
出处 《重庆医科大学学报》 CAS CSCD 2008年第2期186-188,共3页 Journal of Chongqing Medical University
关键词 PTEN 子宫内膜样腺癌 免疫组织化学 PTEN Endometrial carcinoma Immunohistochemical method
分类号 R737.6 [医药卫生—肿瘤]
  • 相关文献

参考文献11

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二级参考文献31

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共引文献12

同被引文献17

  • 1姚勤,戴淑真,车艳辞,罗兵.子宫内膜癌及其癌前病变组织中PTEN基因突变的研究[J].肿瘤防治杂志,2005,12(10):725-728. 被引量：3
  • 2赵岩,银铎,杨清,张淑兰.PTEN和p53蛋白在子宫内膜癌组织中的表达及临床意义[J].中华肿瘤防治杂志,2007,14(6):443-446. 被引量：8
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引证文献2

二级引证文献4

重庆医科大学学报
2008年 第2期

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