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肠三叶因子对坏死性小肠结肠炎大鼠IL-6及IL-10的影响及意义 被引量：1

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摘要 坏死性小肠结肠炎（necrotizing enterocolitis，NEC）是新生儿期的一种肠道炎症疾病，尤其好发于早产儿和（或）低出生体重儿，严重时可危及患儿生命。NEC的发病与早产、肠管缺血一缺氧性损伤、肠道功能及机体抵抗力未成熟、肠道喂养和细菌感染等有关。这些危险因素导致炎症介质的大量产生，随着局部炎症级联反应的激活，在细胞水平上发生一系列的变化从而导致肠坏死。肠三叶因子（intestinal trefoil factor，ITF）为三叶肽家族成员之一，
作者 石磊 张丙宏 于红刚 于皆平
机构地区 武汉大学人民医院消化科 武汉大学人民医院儿科
出处 《中华围产医学杂志》 CAS 2008年第2期125-127,共3页 Chinese Journal of Perinatal Medicine
关键词 坏死性小肠结肠炎 肠三叶因子 IL-10 IL-6 TREFOIL 大鼠 低出生体重儿 肠道功能
分类号 R725.746.2 [医药卫生—儿科] R573 [医药卫生—消化系统]
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参考文献10

  • 1Crissinger KD. Animal models of necrotizing enterocolitis. J Pediatr Gastroenterol Nutr, 1995,20 : 17-22.
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同被引文献14

  • 1严彩霞,张丙宏,石磊.肠三叶因子对坏死性小肠结肠炎新生鼠白细胞介素-6的影响[J].实用儿科临床杂志,2007,22(14):1072-1073. 被引量：4
  • 2Yost CC.Neonatal necrotizing enterocolitis:diagnosis,management,and pathogenesis.J Infu Nurs,2005,28(2):130-134.
  • 3Kjellev S,Vestergaard EM,Nex E,et al.Pharmacokinetics of trefoil peptides and their stability in gastrointestinal contents.Peptides,2007,28(6):1197-1206.
  • 4Aurelie Le Mandat Schultz,Arnaud Bonnard.Expression of TLR-2,TLR-4,NOD2 and pNF-κB in a neonatal rat model of necrotizing enterocolitis.PLoS One,2007,2(10):1100-1102.
  • 5Wei Hsueh,Isabelle G,De Plaen,et al.Neonatal enterocolitis:clinical aspects,experimental models and pathogenesis.World J Pediatr,2007,3(1):17-29.
  • 6Anand RJ,Leaphart CL,Mollen KP,et al.The role of the intestinal barrier in the pathogenesis of necrotizing enterocolitis.Shock,2007,27(2):124-133.
  • 7Madsen J,Nielsen O,Tornфe I.Tissue localization of human trefoil factors 1,2,and 3.Histochem Cytochem,2007,55(5):505-513.
  • 8Fueger PT,Schisler JC,Lu D,et al.Trefoil factor 3 stimulates human and rodent pancreatic is let beta-cell replication with retention of function.Molecular Endocrinology,2008,22(5):1251-1259.
  • 9Meyerzum Büschenfelde D,Tauber R,Huber O.TFF3-peptide increases transepithelial resistance in epithelial cells by modulating claudin-1 and -2 expression.Peptides,2006,27(12):3383-3390.
  • 10Zhu S,Evans S,Yan B,Povsic TJ.Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells.Circulation,2008,118(21):2156-2165.

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中华围产医学杂志
2008年 第2期

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