摘要
目的:探讨Creutzfeldt-Jakob病(Creutzfeldt-Jakob disease,CJD)临床早期诊断方法。方法:对2例CJD病患者的临床表现、影像学特点、脑电图改变等资料进行回顾性分析和总结。结果:2例均符合国人CJD临床特点。弥散加权成像(DWI)能检测出特征性病灶,较目前WHO的CJD诊断方法更具敏感性。结论:提高临床医师对本病临床特征性的认识,可以尽早作出正确诊断,减少医源性传播;作为无创性检查的DWI在CJD诊断方法中最具敏感性,临床诊断标准中应考虑DWI检查的列入。
Objective： To investigate the early clinical diagnosis of Creutzfeldt-Jakob disease （CJD）. Methods： The clinical manifestation, electroencephalogram （EEG） and imaging data of two cases of CJD were analyzed retrospectively. Results：There were special clinical characteristics of CJD in Chinese. The characteristic lesions were detected by diffusion-weighted imaging （DWI） in both of the two cases. DWI was more sensitive than the current clinical diagnosis method suggested by WHO. Conclusions ： Recognition of the clinical characteristics of CJD in Chinese is helpful to early and correct diagnosis of the disease and can reduce the iatrogenic transmission. DWI, a non-invasive diagnostic method,is the most sensitive test for the early diagnosis of CJD and consideration should be given to its inclusion in the clinical diagnostic criteria of CJD.
出处
《蚌埠医学院学报》
CAS
2008年第2期155-157,共3页
Journal of Bengbu Medical College
