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前列腺干细胞抗原和PTEN蛋白在前列腺癌组织中的表达及其相关性 被引量：2

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摘要 前列腺干细胞抗原（prostate stem cell antigen，PSCA）是一种前列腺特异性的细胞表面抗原，而第10号染色体缺失的磷酸酶和张力蛋白同源物基因（PTEN）是一种具有双特异磷酸酶活性的抑癌基因。为了探讨PSCA和PTEN在BPH和PCa组织中的表达相关性以及与PCa临床分期及病理分级的关系，
作者 李树平 谭常兰 姚利萍 刘永红 尹利华
机构地区 怀化医学高等专科学校检验系 怀化医学高等专科学校附属医院检验科 怀化市第一人民医院检验科
出处 《中华男科学杂志》 CAS CSCD 2008年第3期272-274,共3页 National Journal of Andrology
基金 湖南省教育厅科研基金项目(03C041)
关键词 前列腺癌 前列腺干细胞抗原 PTEN蛋白 免疫组织化学
分类号 R737.25 [医药卫生—肿瘤] R446.62 [医药卫生—诊断学]
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参考文献6

二级参考文献43

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共引文献42

同被引文献21

  • 1Jain S,Bhojwani AG,Mellon JK.Improving the utility of prostatespecific antigen(PSA)in the diagnosis of prostate cancer:the use ofPSA derivatives and novel markers[J].Postgrad Med J,2002,78:646-650.
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  • 3Punglia RS,D'Amico AV,Catalona WJ,et al.Effect of verification bi-as on screening for prostate cancer by measurement of prostate-spe-cific antigen[J].N Eng1 J Med,2003,349:335-342.
  • 4Cairns P,Okami K,Halachmi S,et al.Frequent inactivation ofPTEN/MMAC1 in primary prostate cancer[J].Cancer Res,1997,57:4997-5000.
  • 5Suzuki H,Freije D,Nusskern DR,et al.Interfocal heterogeneity ofPTEN/MMAC1 gene alterations in multiple metastatic prostate cancertissues[J].Cancer Res,1998,58(2):204-209.
  • 6Wang SI,Panson R,Ittmann M.Homozygous deletion of the PTENtumor suppressor gene in a subset of prostate adenocarci2 nomas[J].Clin Cancer Res,1998,4(3):811-815.
  • 7Li J,Yen C,Liaw D,et al.PTEN,a putative protein tyrosine phos-phatase gene mutated in human brain,breast,and prostate cancer[J].Science,1997,275(5308):1943-1947.
  • 8Steck PA,Pershouse MA,Jasser SA,et al.Identification of a candi-date tumor suppressor gene,MMACl,at chromosome 10q23.3 that ismutated in multiple advanced cancers[J].Nat Genet,1997,15(4):356-362.
  • 9Li DM,Sun H.TEP1,encoded by a candidate tumor suppressor lo-cus,is a novel protein tyrosine phosphatase regulated by trans2 form-ing growth foctor beta[J].Cancer Res,1997,57(11):2124-2129.
  • 10Whang YE,Wu X,Suzuki H,et al.Inactivation of the tumor sup-pressor PTENΠMMAC1 in advanced human prostate cancer throughloss of expression[J].Proc Natl Acad Sci USA,1998,95(9):5246-5250.

引证文献2

中华男科学杂志
2008年 第3期

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