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哇硫平联合碳酸锂或丙戊酸钠治疗双相躁狂的多中心随机对照研究

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摘要 目的探讨哇硫平合并碳酸锂或丙戊酸钠治疗双相踩狂的疗效和安全性。方法将符合CCMD--3和DSM--IV的双相障碍诊断标准的100倒研究对象随机分成2组,53倒哇硫平组应用哇硫平合并碳酸锂或丙戊酸钠,47倒对照组单一使用碳酸锂或丙戊酸钠,治疗观察6wk。采用Beck--RafaelS。踩狂量表(BRMS)评定疗效,以副反应量表(TESS)及实验室有关辅助检查评价安全性。结果哇硫一平组的45倒(85%)和对照组的40倒(85%)完成了6wk的治疗观察,哇硫平组在治疗wkl末的减分率比对照组显著,这种盖异在1~6wk一直存在,而且6wk结束后的临床有效率(BRMS减分率)50%),痊愈率(BRMS〈11)也显著高于对照组。哇硫平合并碳酸钠或丙戊酸钠常见的不良反应有头晕,头痛、嗜睡、心悸、口干、直立性低血压、便秘。结论哇硫平合并碳酸锂或丙戊酸钠治疗双相踩狂的疗效比单一使用心境稳定剂好。
出处 《中外医疗》 2008年第3期28-30,共3页 China & Foreign Medical Treatment
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