摘要
内蒙古医学院第二附属医院骨肿瘤科于1999-10/2006-08对33例骨肿瘤(恶性10例,良性23例)患者进行瘤段切除特制假体置换,假体材料为不锈钢或钴铬钼合金或钛合金,由北京力达康科技有限公司设计并定做。所有患者均同意外科手术并签订知情同意书和特制假体置换协议书。随访6～70个月,除l例髋骨体骨巨细胞瘤、2例滑膜肉瘤、1例恶性纤维组织细胞瘤患者死于肺转移外,其他病例无局部复发和转移,无骨折现象发生,l例膝关节术后感染并僵直,3例膝关节置换后大腿中段(假体与股骨连接处)疼痛;按Enneking肢体肌肉骨骼肿瘤外科治疗重建术后功能综合评分:上肢优良率80%;下肢优良率86.4%。肩关节疼痛缓解率为90%,主动活动增加;髋关节活动基本正常;膝关节屈伸活动0°～100°。1例膝关节不锈钢假体出现了排斥反应,2例考虑假体与股骨连接处松动,其他假体与组织的生物相容性较好。
Thirty-three patients with bone tumor （malignant in 10 cases and benign in 23 cases） selected from Department of Bone Tumor, the Second Affiliated Hospital of Mongolian Medical College from October 1999 to August 2006 underwent special prosthetic replacement at neoplastic segment. The prosthesis was made of stainless steel, alloy of cobalt-chrome-molybdenum, or titanium alloy, which are provided by Beijing Lidakang Technology Company Limited. All patients provided the confirmed consent. In the follow-up of 6-70 months, one patient with giant cell tumor of haunch bone, two patients with malignant synovioma, and one patient with malignant fibrous histiocytoma died due to pulmonary metastasis, In all those patients who survived, none have local recidivation, transferring, or fracture. Among them, one patient had postoperative infection and rigor at knee joint. Three patients had ache at middle part of thigh （junction between prosthesis and femoral bone） after knee joint replacement. According to the Enneking scores after reconstruction of surgical oncology, fineness rate of upper limbs was 80%, and that of lower limbs was 86.4%. Odynolysis rate of shoulder joint was 90%. Active movement was increased and activity of femoral articulation was generally normal. Extension and flexion of knee joint ranged from 0 to 100 degree. Rejection occurred in stainless steel prosthesis of knee joint in one patient. Junction between prosthesis and femoral bone was loose in two cases. All other prostheses had great biocompatibility to tissues.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第9期1775-1781,共7页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
内蒙古自治区卫生厅资助项目(内卫2001-8)~~
