摘要
树突状细胞（dendritic cells，DC）通过激活初始T细胞、诱导Th2免疫应答偏移和维持气道炎症，以及负性调节作用，影响支气管哮喘（哮喘）疾病的发生、发展．是哮喘免疫应答的启动者、参与者和调节者。DC在免疫应答中的关键地位提示我们它可作为防治哮喘疾病的一个重要靶点。
Dendritic cells （DC） influence generation and development of asthma not only through activing naive T cells,inducing Th2 responses,maintaining respiratory inflammatory response but also down regulating the process. On the whole DC are priming factors, participants and modulators. DC represent a therapeutic target to prevent the development of asthma because of the critical role in immune response.
出处
《国际呼吸杂志》
2008年第7期409-413,共5页
International Journal of Respiration
关键词
树突状细胞
哮喘
炎症
免疫耐受
Dendritic cells
Asthma
Inflammation
Tolerance
