摘要
目的:探讨不同剂量辛伐他汀早期干预治疗对急性心肌梗死患者血清白介素-6水平及核因子κB活性的影响。方法:将60例急性心肌梗死患者随机分为2组,每组各30例;A组为20 mg辛伐他汀治疗组;B组为40 mg辛伐他汀治疗组;30例稳定性心绞痛患者为对照组。A、B两组患者在治疗前及治疗2周后分别测定血清白介素-6、血脂水平及核因子κB活性。结果:A、B两组患者的血清白介素-6水平、核因子κB活性明显高于对照组(P<0.05)。A、B两组治疗2周后血清白介素-6水平、核因子κB活性均有明显下降(P值<0.05),而以B组作用更明显。结论:急性心肌梗死患者血清炎症因子水平增高,核因子κB激活,早期辛伐他汀治疗可降低急性心肌梗死患者的血清白介素-6水平和抑制核因子κB活性,且呈剂量依赖性。早期他汀类药物强化治疗可能使急性心肌梗死患者获益更大。
Objective To investigate the effects of different doses of simvastatin on serum levels of IL-6 and nuclear factor κB activity in the early phase of acute myocardial infarction. Methods Sixty patients with acute myocardial infarction were randomly divided into two groups. Thirty patients in group A were given routine therapy and 20 mg simvastatin once daily for 2 weeks; Thirty patients in group B were given routine therapy and 40 mg simvastatin once daily for 2 weeks. Another 30 patients with stable angina served as controls. The serum levels of IL-6 and nuclear factor κB activity were measured before and after therapy. Results The serum levels of IL-6 and nuclear factor κB activity in the patients with acute myocardial infarction were significantly higher than those in control group （P 〈0.05）. The serum levels of IL-6 and nuclear factor κB activity significantly lowered after two weeks of therapy with simvastatin（P〈0.05）, especially in the 40 mg simvastatin group. Conclusion The activation of nuclear κB in peripheral blood is significantly higher in patients with acute myocardial infarction. The serum levels of inflammatory factors including IL-6 are increased in patients with acute myocardial infarction and early simvastatin intervention may decrease dose-dependently the serum levels of IL-6 and activation of nuclear factor κB. Early intensive simvastatin treatment may yield more significant benefits in the patients with acute myocardial infarction.
出处
《实用诊断与治疗杂志》
2008年第4期249-251,共3页
Journal of Practical Diagnosis and Therapy
